The study of O-GlcNAc, a ubiquitous translation and transcription regulator which is found in a wide variety of proteins, is of great relevance to multiple chronic human and veterinary diseases. These include diabetes (and its effects in the heart, kidneys and eyes), cardiovascular disease, neurodegenerative disorders involving both plaque and tangle formation, inflammatory processes, liver […]
| Inventor | Institute |
|---|---|
| Lance Wells | University of Georgia |
| Cat. #: | 153904 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell signaling and signal transduction;Genetics;Metabolism;Neurobiology |
| Application: | ELISA ; WB |
| Target: | O-linked N-acetylglucosamine |
| Reactivity: | Mammals |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | O-GlcNAc |
|---|---|
| Product description: | The study of O-GlcNAc, a ubiquitous translation and transcription regulator which is found in a wide variety of proteins, is of great relevance to multiple chronic human and veterinary diseases. These include diabetes (and its effects in the heart, kidneys and eyes), cardiovascular disease, neurodegenerative disorders involving both plaque and tangle formation, inflammatory processes, liver disease, fibrosis, metabolic disorders and cancer. There is fast growing collection of evidence that O-GlcNAcylation plays a pivotal role in epigenetics. |
| Conjugation: | Unconjugated |
| Isotype: | IgG3 |
| Immunogen: | Synthetic peptide O-GlcNAc |
| Target background: | The study of O-GlcNAc, a ubiquitous translation and transcription regulator which is found in a wide variety of proteins, is of great relevance to multiple chronic human and veterinary diseases. These include diabetes (and its effects in the heart, kidneys and eyes), cardiovascular disease, neurodegenerative disorders involving both plaque and tangle formation, inflammatory processes, liver disease, fibrosis, metabolic disorders and cancer. There is fast growing collection of evidence that O-GlcNAcylation plays a pivotal role in epigenetics. |
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| Format: | Liquid |
|---|---|
| Shipping conditions: | Dry ice |
| References: |
Rios et al. 2016. Angew Chem Int Ed Engl. 55(10):3387-92. PMID: 26822115. Synthetic Receptors for the High-Affinity Recognition of O-GlcNAc Derivatives. Teo et al. 2010. Nat Chem Biol. 6(5):338-43. PMID: 20305658. Glycopeptide-specific monoclonal antibodies suggest new roles for O-GlcNAc. |
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