Anti-human NKG2D is a monoclonal antibody to NKD2D is focused on providing a new approach for the early detection and treatment of a cancer type characterized by expressing ZIP4, preferably pancreatic cancer.
| Inventor | Institute |
|---|---|
| Thomas Spies; Veronika Groh | Fred Hutchinson Cancer Center |
| Cat. #: | 161645 |
|---|---|
| Tool sub type: | Primary antibody |
| Cancer types: | Breast cancer;Genitourinary cancer;Gynaecologic cancer;Lung cancer |
| Research Fields: | Immunology |
| Application: | IP, Function Blocking |
| Target: | MICA receptor NKG2D, Collagen type VI |
| Reactivity: | Human, Mouse |
| Clone: | 5C6 |
| Host: | Mouse |
| Class: | Monoclonal |
| Primary citation: | BauerS et al. 1999. Science. 285(5428):727-9. PMID: 10426993 |
| Product description: | Anti-human NKG2D is a monoclonal antibody to NKD2D. NKG2D is a MICA Receptor found on ?? T cells and CD8+ ?? T cells, natural killer (NK) cells and is frequently expressed in epithelial tumors. The 1D11 antibody blocks MICA binding to T cells, induces redirected lysis, and costimulates T cells activation and proliferation |
|---|---|
| Isotype: | IgG1, ? |
| Molecular weight: | 42kDa |
| Target background: | NKG2D is a receptor for MICA detected on most ?? T cells, CD81 ?? T cells, and natural killer (NK) cells. Effector cells from all these subsets could be stimulated by ligation of NKG2D. Engagement of NKG2D activated cytolytic responses of ?? T cells and NK cells against transfectants and epithelial tumor cells expressing MICA. |
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| Storage conditions: | The antibody solution should be stored undiluted between 2° C and 8° C, and protected from prolonged exposure to light. Do not freeze.For immediate use, short term storage at 4° C up to two weeks is recommended. For long term storage, divide the solution into volumes of no less than 20 ul for freezing at -20° C or -80° C. The small volume aliquot should provide sufficient reagent for short term use. Freeze-thaw cycles should be avoided. |
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| Shipping conditions: | Dry ice |
| References: |
BauerS et al. 1999. Science. 285(5428):727-9. DOI: 10.1126/science.285.5428.727 V. Groh et al.1998. Science 279(1737).PMID: 9497295 |
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