The MRCKLRAP35a-MYO18A complex plays a major role in the assembly of the lamellar actomyosin retrograde flow bundles important for persistent membrane protrusion. The complex may also represent a mode of transmitting signals from leading edge to cell center, as part of the coordination mechanism important for efficient and persistent directional migration.
| Inventor | Institute |
|---|---|
| Thomas Leung | A*STAR Accelerate Technologies Pte Ltd |
| Cat. #: | 154120 |
|---|---|
| Unit size: | 100 ug |
| Research Fields: | Cell biology |
| Application: | IP ; WB |
| Target: | MRCKÄÂ? |
| Class: | Monoclonal |
| Product description: | The MRCKLRAP35a-MYO18A complex plays a major role in the assembly of the lamellar actomyosin retrograde flow bundles important for persistent membrane protrusion. The complex may also represent a mode of transmitting signals from leading edge to cell center, as part of the coordination mechanism important for efficient and persistent directional migration. |
|---|---|
| Conjugation: | Unconjugated |
| Target background: | The MRCKLRAP35a-MYO18A complex plays a major role in the assembly of the lamellar actomyosin retrograde flow bundles important for persistent membrane protrusion. The complex may also represent a mode of transmitting signals from leading edge to cell center, as part of the coordination mechanism important for efficient and persistent directional migration. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Tan et al. 2008. Cell. 135(1):123-36. PMID: 18854160. A tripartite complex containing MRCK modulates lamellar actomyosin retrograde flow. |
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