For the detection of Notch 1 of mouse, rat and human origin. This mN1A antibody has been reported for use in intracellular staining followed by flow cytometric analysis, immunoblotting (WB), and immunohistochemical staining.
| Inventor | Institute |
|---|---|
| Laurie Milner | Fred Hutchinson Cancer Center |
| Cat. #: | 161667 |
|---|---|
| Tool sub type: | Primary antibody |
| Research Fields: | Cell biology |
| Application: | Flow Cytometry, IP, WB, IHC-Fr, ICC |
| Target: | Notch1 protein |
| Reactivity: | Human, Mouse. |
| Clone: | Mn1a |
| Host: | Mouse |
| Class: | Monoclonal |
| Primary citation: | Huppert et al.2000. Nature. 405[6789):966-70. PMID: 10879540 |
| Product description: | Antibody mN1A recognizes Notch 1, one of the four major transmembrane receptors (Notch 1-4) of the Notch signaling pathway, which is activated through binding to DSL domain-containing membrane-bound specific ligands. |
|---|---|
| Isotype: | IgG1 |
| Target background: | Intracellular domain of Notch1 protein, mainly its activated form. The Notch genes encode single-pass transmembrane receptors that transduce the extracellular signals responsible for cell fate determination during several steps of metazoan development. |
|---|
| Storage conditions: | Shipped at 4° C. Upon delivery aliquot and store at -20° C. Avoid freeze / thaw cycles. |
|---|---|
| Shipping conditions: | Dry ice |
| References: |
Huppert et al.2000. Nature. 405[6789):966-70.PMID: 10879540 |
|---|
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