Anti-MMP1 [3B6]

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Name: Anti-MMP1 [3B6]
• Research fields: Cancer;Cell biology;Genetics;Tissue-specific biology
• Clone: 3B6
• Tool sub type: Primary antibody
• Class: Monoclonal
• Conjugation: Unconjugated
• Strain: Balb/c
• Reactivity: Human
• Host: Mouse
• Application: IHC ; IF ; IP ; WB
• Description: MMP1 cleaves collagens of types I, II, and III at one site in the helical domain. MMP1 also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.
• Immunogen: Ovalbumin-conjugated synthetic peptide; CSSFGFPRTVKH
• Isotype: IgG1
• Myeloma used: P3X63Ag8.653
• Recommended controls: IHC: formalin-fixed, paraffin-embedded colonic adenocarcinomaWestern blot: rhMMP-1, 400 ng per lane

Target Details

• Target: Human matrix metalloproteinase 1 (MMP-1)
• Tissue cell line specificity: IHC: formalin-fixed, paraffin-embedded colonic adenocarcinomaWestern blot: rhMMP-1, 400 ng per lane
• Target background: MMP1 cleaves collagens of types I, II, and III at one site in the helical domain. MMP1 also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.

Applications

• Application: IHC ; IF ; IP ; WB

Handling

• Format: Liquid
• Unit size: 100 ug
• Storage buffer: PBS with 0.02% azide
• Storage conditions: -80° C
• Shipping conditions: Shipping at 4° C

References

• Jeffery et al. 2009. Histopathology. 54(7):820-8. PMID: 19635101.
• The matrix metalloproteinase/tissue inhibitor of matrix metalloproteinase profile in colorectal polyp cancers.
• Lyall et al. 2006. Clin Cancer Res. 12(4):1184-91. PMID: 16489072.
• Profiling markers of prognosis in colorectal cancer.
• Curran et al. 2004. Clin Cancer Res. 10(24):8229-34. PMID: 15623598.
• Matrix metalloproteinase/tissue inhibitors of matrix metalloproteinase phenotype identifies poor prognosis colorectal cancers.
• Murray et al. 1998. Gut. 43(6):791-7. PMID: 9824606.
• Matrix metalloproteinases and their inhibitors in gastric cancer.
• Murray et al. 1998. J Pathol. 185(3):256-61. PMID: 9771478.
• Matrix metalloproteinase-1 is associated with poor prognosis in oesophageal cancer.
• Murray et al. 1996. Nat Med. 2(4):461-2. PMID: 8597958.
• Matrix metalloproteinase-1 is associated with poor prognosis in colorectal cancer.