HLA-DQ (DQ) is a cell surface receptor protein found on antigen presenting cells. It is an a? heterodimer of type MHC class II. The a and ? chains are encoded by two loci, HLA-DQA1 and HLA-DQB1, that are adjacent to each other on chromosome band 6p21.3. Both a-chain and ?-chain vary greatly. A person often produces two a-chain and two ?-chain variants and thus 4 isoforms of DQ.
| Institute |
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| Netherlands Cancer Institute |
| Cat. #: | 154752 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell signaling and signal transduction;Immunology |
| Application: | FACS ; IHC ; IP |
| Target: | MHC class II HLA-DQ |
| Reactivity: | Human ; Pig |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | HLA-DQ (DQ) is a cell surface receptor protein found on antigen presenting cells. It is an ÄÂ?ÄÂ? heterodimer of type MHC class II. The ÄÂ? and ÄÂ? chains are encoded by two loci, HLA-DQA1 and HLA-DQB1, that are adjacent to each other on chromosome band 6p21.3. Both ÄÂ?-chain and ÄÂ?-chain vary greatly. A person often produces two ÄÂ?-chain and two ÄÂ?-chain variants and thus 4 isoforms of DQ. |
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| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Immunogen: | Cloned cytotoxic T lymphocytes. |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | HLA-DQ (DQ) is a cell surface receptor protein found on antigen presenting cells. It is an a? heterodimer of type MHC class II. The a and ? chains are encoded by two loci, HLA-DQA1 and HLA-DQB1, that are adjacent to each other on chromosome band 6p21.3. Both a-chain and ?-chain vary greatly. A person often produces two a-chain and two ?-chain variants and thus 4 isoforms of DQ. |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
te Velde et al. 1988. J Immunol. 140(5):1548-54. PMID: 3279117. Spits et al. 1984. Eur J Immunol. 14(4):299-304. PMID: 6609821. Spits et al. 1983. Hybridoma. 2(4):423-37. PMID: 6332061. |
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