C8/144B can be used to detect these cells in tissue sections and also their neoplastic counterparts.
| Inventor | Institute |
|---|---|
| Jacqueline Cordell | University of Oxford |
| Cat. #: | 151345 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Cancer types: | Blood cancer |
| Research Fields: | Immunology;Stem cell biology |
| Application: | IHC ; IF ; IP ; WB |
| Target: | Leu2 (CD8) |
| Reactivity: | Human |
| Clone: | C8/144B |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | CD8a Molecule; T-Lymphocyte Differentiation Antigen T8/Leu-2; CD8 Antigen; Alpha Polypeptide (P32); MAL; T-Cell Surface Glycoprotein CD8 Alpha Chain; Leu2 T-Lymphocyte Antigen; OKT8 T-Cell Antigen; T-Cell Antigen Leu2; T8 T-Cell Antigen; CD8a Antigen; Leu2; P32 |
|---|---|
| Product description: | C8/144B can be used to detect these cells in tissue sections and also their neoplastic counterparts. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | Synthetic peptide (the 13 C-terminal residues of the cytoplasmic domain of human CD8a) |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Target background: | CD8 is a T cell co-receptor that recognises, together with the T cell receptor, MHC class I molecules. CD8 is present on human suppressor/cytotoxic T cells which make up 30% of circulating T cells. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
van Gool et al. 2015. Clin Cancer Res. 21(14):3347-55. PMID: 25878334. POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer. Harlin et al. 2009. Cancer Res. 69(7):3077-85. PMID: 19293190. Chemokine expression in melanoma metastases associated with CD8+ T-cell recruitment. Sato et al. 2005. Proc Natl Acad Sci U S A. 102(51):18538-43. PMID: 16344461. Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. Mason et al. 1992. J Clin Pathol. 45(12):1084-8. PMID: 1479035. Immunohistological detection of human cytotoxic/suppressor T cells using antibodies to a CD8 peptide sequence. |
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