Cat. #151176
Anti-Leu1 [UCH-T2]
Cat. #: 151176
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 1-2 weeks
Target: Leu1 (CD5)
Class: Monoclonal
Application: IHC ; IF ; WB
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Peter Beverley
Institute: University College London (UCL)
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-Leu1 [UCH-T2]
- Alternate name: CD5 Molecule 2; Lymphocyte Antigen T1/Leu-1; LEU1; CD5 Antigen; T1
- Cancer: Blood cancer
- Cancers detailed: Leukemia;Lymphoma
- Research fields: Immunology;Stem cell biology
- Clone: UCH-T2
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Strain: Balb/c
- Reactivity: Human
- Host: Mouse
- Application: IHC ; IF ; WB
- Description: UCH-T2 is useful for detection of T cells in peripheral blood and lymph nodes and categorisation of T cell lymphomas and B cell chronic lymphocytic leukaemia.
- Immunogen: Thymocytes followed by Sezary T cells.
- Immunogen uniprot id: P04234
- Isotype: IgG1 kappa
- Myeloma used: P3/NS1/1-Ag4.1
- Additional notes: UCH-T1ÄšËis a registered trademark of Cancer Research Technology, Limited. All rights reserved.
Target Details
- Target: Leu1 (CD5)
- Target background: Leu-1 is a surface glycoprotein present on peripheral T cells (>95%) and B-cell chronic lymphocytic leukaemia cells that binds CD72. Absence of the Leu-1 marker on childhood ALL cells is associated with a more favourable prognosis.
Applications
- Application: IHC ; IF ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
Related Tools
- Related tools: Anti-CD3, Recombinant [UCH-T1?‚™]
References
- Beverley PE & Callard RE. 1982. Protides Biol. Fluids. Colloq. 29:653-8.
- Kap et al. 2009. J Histochem Cytochem. 57(12):1159-67. PMID: 19729671.
- A monoclonal antibody selection for immunohistochemical examination of lymphoid tissues from non-human primates.
- Gary-Gouy et al. 2007. J Immunol. 179(7):4335-44. PMID: 17878328.
- Natural phosphorylation of CD5 in chronic lymphocytic leukemia B cells and analysis of CD5-regulated genes in a B cell line suggest a role for CD5 in malignant phenotype.
