Location-regulated scaffolding protein connecting MEK to RAF.
| Inventor | Institute |
|---|---|
| Richard Marais | The Institute of Cancer Research |
| Cat. #: | 153392 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell signaling and signal transduction |
| Application: | IHC ; WB |
| Target: | KSR |
| Reactivity: | Human ; Mouse ; Rat |
| Clone: | MINT/1/14 |
| Host: | Rat |
| Class: | Monoclonal |
| Alternate name: | RSU2; KSR |
|---|---|
| Product description: | Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity. In unstimulated cells, where the phosphorylated form is bound to a 14-3- 3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, and it moves from the cytoplasm to the cell periphery. |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Molecular weight: | 140 kDa |
| Immunogen: | Recombinant human KSR protein |
| Target background: | Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity. In unstimulated cells, where the phosphorylated form is bound to a 14-3- 3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, and it moves from the cytoplasm to the cell periphery. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
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