Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue- and differentiation-specific expression profiles. Keratins 1 and 10 are differentiation-specific keratins that are the predominant keratins in suprabasal keratinocytes […]
| Inventor | Institute |
|---|---|
| Irene Leigh | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 153430 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell biology |
| Application: | ELISA ; IHC ; WB |
| Target: | Keratin 10 |
| Reactivity: | Human |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | CK 1 antibody, CK-1 antibody, Cytokeratin-1 antibody, EHK antibody, K1 antibody, K1C1_HUMAN antibody, Keratin 1 antibody, Keratin 1 type I antibody, Keratin antibody, Keratin type i cytoskeletal 1 antibody, Keratin type I cytoskeletal 59 kDa antibody,Keratin-1 antibody, Keratin1 antibody, KPP antibody, KRT1 antibody, type I cytoskeletal 1 antibody |
|---|---|
| Product description: | Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue- and differentiation-specific expression profiles. Keratins 1 and 10 are differentiation-specific keratins that are the predominant keratins in suprabasal keratinocytes in stratified epthelia. Keratin 10 is a suprabasal marker of differentiation in stratified squamous epithelia. Mutations in keratins 1 and 10 cause epidermolytic hyperkeratosis. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | Epidermis from Psoriasis patient (crude extract) |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue- and differentiation-specific expression profiles. Keratins 1 and 10 are differentiation-specific keratins that are the predominant keratins in suprabasal keratinocytes in stratified epthelia. Keratin 10 is a suprabasal marker of differentiation in stratified squamous epithelia. Mutations in keratins 1 and 10 cause epidermolytic hyperkeratosis. |
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| Format: | Liquid |
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| Shipping conditions: | Dry ice |
| References: |
Lane et al. 1985. Ann N Y Acad Sci. 455:241-58. PMID: 2417515. Keratin antigens in differentiating skin. |
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