#161583

Anti-Integrin alpha3 (CD49c) monoclonal antibody [KU44.22B]

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Cat. #161583

Anti-Integrin alpha3 (CD49c) monoclonal antibody [KU44.22B]

Cat. #: 161583

Sub-type: Primary antibody

Target: Integrin alpha3

Class: Monoclonal

Application: ELISA, IHC, IF, IP, WB, FACS

Reactivity: Human

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Helmout Modjtahedi

Institute: Kingston University

Primary Citation: Arias-Pinilla et al. 2020. Sci Rep. 10(1):537. PMID: 31953437

Tool Details
Target Details
Applications
Related Tools
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: Anti-Integrin alpha3 (CD49c) monoclonal antibody [KU44.22B]
  • Cancer: Pancreatic cancer
  • Cancers detailed: Pancreatic cancer
  • Research fields: Cancer
  • Clone: KU44.22B
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Molecular weight: 110 kDa
  • Reactivity: Human
  • Host: Mouse
  • Disease: Cancer
  • Application: ELISA, IHC, IF, IP, WB, FACS
  • Description: MAb KU44.22B inhibits the growth in vitro of Capan-2 cancer cells, increases migration of BxPC-3 and CFPAC-1 cancer cell lines and induces receptor downregulation and internalisation
  • Immunogen: CFPAC-1 cell line
  • Isotype: IgG1 kappa

Target Details

  • Target: Integrin alpha3
  • Target alternate names: CD49c
  • Molecular weight: 110 kDa
  • Target background: Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion.

Applications

  • Application: ELISA, IHC, IF, IP, WB, FACS

Related Tools

  • Related tools: KU43.13A monoclonal antibody

References

  • Arias-Pinilla et al. 2020. Sci Rep. 10(1):537. PMID: 31953437