Anti-integrin a2 [P1E6]

P1E6 recognizes an epitope that requires activation of the ?2/?1 complex.

Contributors

Inventor Institute
Elizabeth A. Wayner Fred Hutchinson Cancer Center
Cat. #: 161654
Tool sub type: Primary antibody
Research Fields: Cell biology
Application: FACS, Function Blocking, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
Target: Integrin alpha 2 (CD49b)
Reactivity: Human
Clone: P1E6
Host: Mouse
Class: Monoclonal
Primary citation: Wayner et al. 1987. Journal of Cell Biology.105(4):1873-84. PMID: 2822727
Product description: Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. Integrin ?2 (P1E6) is a mouse monoclonal antibody raised against HT-1080. Antibodies were developed to identify four distinct classes (I, II, III, IV) of cell surface receptors for native collagen. This antibody was found to Inhibit binding to collagens recpetors I, III, IV and VI.
Isotype: IgG1
Molecular weight: Predicted: 129 kDa; Apparent: 150 kDa
Immunogen: HT1080 human fibrosarcoma cell line
Target background: ?2?1 complex of Collagen receptors: I, II, III, IV
Storage conditions: For immediate use, short term storage at 4°C up to two weeks is recommended. For long term storage, divide the solution into volumes of no less than 20 ul for freezing at -20°C or -80°C. The small volume aliquot should provide sufficient reagent for short term use. Freeze-thaw cycles should be avoided. For concentrate or bioreactor products, an equal volume of glycerol, a cryoprotectant, may be added prior to freezing.
Shipping conditions: Dry ice
References:

Wayner et al. 1987. Journal of Cell Biology.105(4):1873-84.PMID: 2822727

Kamata et al.1994.J Biol Chem. 269(13):9659-63.PMID: 7511592

Tuckwell et al. 1995.J Cell Sci. 108 ( Pt 4):1629-37.PMID: 7615681

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