Cat. #158055
Anti-IL31
Cat. #: 158055
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 10-12 weeks
Target: Interleukin 31
Class: Polyclonal
Application: ELISA ; WB
Reactivity: Horse
Host: Rabbit
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Abdo Alnabulsi
Institute: Vertebrate Antibodies Limited
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-IL31
- Research fields: Cell biology;Immunology
- Tool sub type: Primary antibody
- Class: Polyclonal
- Purpose: Marker
- Conjugation: Unconjugated
- Molecular weight: 17.7 kDa
- Reactivity: Horse
- Host: Rabbit
- Application: ELISA ; WB
- Description: IL-31 is an inflammatory cytokine that modulates cell-mediated immunity against pathogens. It is produced by activated CD4+ T lymphocytes, in particular activated Th2 helper cells, mast cells, macrophages, and dendritic cells. It's major sites of action are the skin, lung, intestine and the nervous system. IL-31 signals via a receptor complex that is composed of IL-31 receptor A (IL31RA) and oncostatin M receptor (OSMR) subunits. These receptor subunits are expressed in activated monocytes and in unstimulated epithelial cells. It was reported when IL-31 is overexpressed in transgenic mice, it results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development. IL-31 and its receptors are also involved in regulating hematopoietic progenitor cell homeostasis.The antibody will elucidate the role of IL-31 in horse and shed further light on its clinical significance.
- Immunogen: Ovalbumin-conjugated synthetic peptide
- Recommended controls: ELISA: Peptide immunogens & recombinant IL-31 WB: Recombinant IL-31
Target Details
- Target: Interleukin 31
- Molecular weight: 17.7 kDa
- Tissue cell line specificity: Rabbit
- Target background: IL-31 is an inflammatory cytokine that modulates cell-mediated immunity against pathogens. It is produced by activated CD4+ T lymphocytes, in particular activated Th2 helper cells, mast cells, macrophages, and dendritic cells. It's major sites of action are the skin, lung, intestine and the nervous system. IL-31 signals via a receptor complex that is composed of IL-31 receptor A (IL31RA) and oncostatin M receptor (OSMR) subunits. These receptor subunits are expressed in activated monocytes an...
Applications
- Application: ELISA ; WB
Handling
- Format: Liquid
- Unit size: 100 ug
- Storage buffer: Unpurified anti-serum from rabbit preserved in 0.02% Thiomersal
- Shipping conditions: Shipping at 4° C
