Antibody to GSK-3 family of kinases, implicated in various cellular processes and cancer development. The phosphorylated peptide used as immunogen derives from a region of the catalytic domain (between sub-domain VII and VIII) of the Drosophila GSK-3 /shaggy enzyme. Clone 5G-2F was selected to react on the phospho-peptide but not on the non phosphorylated peptide. This antibody will not react on GSK-3 or shaggy proteins expressed in E coli, but will react on the respective natural enzymes or those expressed in Sf9 cells. The observed preference for the phosphorylated form is about 50/1. The overall selection over other P-tyr proteins…
| Institute |
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| Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC) |
| SKU: | 162407 |
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| Product description: | Antibody to GSK-3 family of kinases, implicated in various cellular processes and cancer development. The phosphorylated peptide used as immunogen derives from a region of the catalytic domain (between sub-domain VII and VIII) of the Drosophila GSK-3 /shaggy enzyme. Clone 5G-2F was selected to react on the phospho-peptide but not on the non phosphorylated peptide. This antibody will not react on GSK-3 or shaggy proteins expressed in E coli, but will react on the respective natural enzymes or those expressed in Sf9 cells. The observed preference for the phosphorylated form is about 50/1. The overall selection over other P-tyr proteins may be at least around 20/1. |
| Additional notes: | Avoid repeat freezing and thawing cycles. Does not contain any preservative. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1, K |
| Immunogen: | Phosphorylated synthetic peptide coupled to ovalbumin: (C) K203QLLHGEPNVS(P)YICSRY219 |
| Cat. #: | 162407 |
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| Research Fields: | Cell signaling and signal transduction |
| Application: | Immunoblotting; Immunohistochemistry : under investigation; Immunoprecipitation : not tested |
| Target: | Shaggy protein kinase family |
| Reactivity: | Drosophila, NOT E.coli |
| Clone: | 5G-2F |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | Another name for the GSK-3 family of kinases, implicated in various cellular processes and cancer development. |
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| Storage conditions: | -20°C (up to 3 years) |
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