Antibody to glycogen synthase kinase 3, a serine/threonine kinase involved in numerous signaling pathways, including those related to cell proliferation and survival in cancer. The peptide used as immunogen derives from a region of the catalytic domain (between sub-domain VII and VIII) of the Drosophila GSK-3 /shaggy enzyme. Because of the extremely high conservation of this region among the known enzymes of many different species clone 4G-1E, which recognizes the Drosophila enzyme, should cross react with all species homologues (cross-reacts effectively with rat, Sch. Pombe, Dictyostelium*).
| Institute |
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| Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC) |
| SKU: | 162406 |
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| Product description: | Antibody to glycogen synthase kinase 3, a serine/threonine kinase involved in numerous signaling pathways, including those related to cell proliferation and survival in cancer. The peptide used as immunogen derives from a region of the catalytic domain (between sub-domain VII and VIII) of the Drosophila GSK-3 /shaggy enzyme. Because of the extremely high conservation of this region among the known enzymes of many different species clone 4G-1E, which recognizes the Drosophila enzyme, should cross react with all species homologues (cross-reacts effectively with rat, Sch. Pombe, Dictyostelium*). |
| Additional notes: | Avoid repeat freezing and thawing cycles. Does not contain any preservative. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1, K |
| Immunogen: | Synthetic peptide coupled to ovalbumin : (C)K203 QLLHGEPNVSYICSRY219 |
| Cat. #: | 162406 |
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| Research Fields: | Cell signaling and signal transduction |
| Application: | WB, IHC, weak in immunoprecipitation |
| Target: | GSK-3 / Shaggy protein kinase family |
| Reactivity: | Drosophila, should also cross react with all species homologues. Cross-reacts effectively with rat, Sch. Pombe, Dictyostelium |
| Clone: | 4G-1E |
| Host: | Mouse |
| Class: | Monoclonal |
| Primary citation: | Harwood et al., Cell (1995) 80 139-148. PMID: 7813009 |
| Target background: | Glycogen synthase kinase 3 is a serine/threonine kinase involved in numerous signaling pathways, including those related to cell proliferation and survival in cancer. |
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| Storage conditions: | -20°C (up to 3 years) |
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