Cat. #152696
Anti-IgM [UCH-B1]
Cat. #: 152696
Sub-type: Secondary antibody
Unit size: 100 ug
Availability: 3-4 weeks
Target: Prolymphocytic leukaemia B cells Leukemia
Class: Monoclonal
Application: IP ; FACS ; IHC ; IF ; Fn
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Peter Beverley
Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-IgM [UCH-B1]
- Alternate name: B-lymphocytes, IgM, B cell antigen receptor (BCR)
- Research fields: Immunology;Stem cell biology
- Clone: UCH-B1
- Tool sub type: Secondary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Molecular weight: 85 kDa
- Strain: Balb/c
- Reactivity: Human
- Host: Mouse
- Application: IP ; FACS ; IHC ; IF ; Fn
- Description: Human surface membrane bound IgM complexes with a heterodimer of transmembrane proteins of Ig alpha and Ig beta (CD79a and CD79b) to form the B cell antigen receptor (BCR). The BCR complex plays an important role in B cell development and activation. The transmembrane region of mIgM is essential for functional BCR complex assembly. Antibody UCHB1 recognizes surface expressed and soluble human IgM.
- Immunogen: Human prolymphocytic leukaemia B cells.
- Isotype: IgG1
- Myeloma used: NS0
Target Details
- Target: Prolymphocytic leukaemia B cells Leukemia
- Molecular weight: 85 kDa
- Target background: Human surface membrane bound IgM complexes with a heterodimer of transmembrane proteins of Ig alpha and Ig beta (CD79a and CD79b) to form the B cell antigen receptor (BCR). The BCR complex plays an important role in B cell development and activation. The transmembrane region of mIgM is essential for Fn BCR complex assembly. Antibody UCHB1 recognizes surface expressed and soluble human IgM.
Applications
- Application: IP ; FACS ; IHC ; IF ; Fn
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
References
- Grupp et al. 1995. J Exp Med. 181(1):161-8. PMID: 7807000.
- Molecular mechanisms that control expression of the B lymphocyte antigen receptor complex.
- DeFranco et al. 1994. Chem Immunol. 59:156-72. PMID: 7945925.
- Structure and function of the B-cell antigen receptor.
- Smith-Ravin et al. 1990. Clin Exp Immunol. 82(1):181-7. PMID: 2208792.
- Characterization of two monoclonal antibodies (UCL4D12 and UCL3D3) that discriminate between human mantle zone and marginal zone B cells.
- Armitage et al. 1988. Eur J Immunol. 18(1):67-76. PMID: 3257923.
- A new antigen identified by the monoclonal antibody UCHB 1 delivers a costimulatory signal to a subset of human B cells.
- Coakham et al. 1984. Lancet. 1(8386):1095-8. PMID: 6202990.
- Use of monoclonal antibody panel to identify malignant cells in cerebrospinal fluid.
