Cat. #152765
Anti-HPV18E6 [C1N1]
Cat. #: 152765
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-4 weeks
Target: Human papillomavirus type 18 (HPV-18) specific epitopes on the E6 polypeptide
Class: Monoclonal
Application: ELISA ; IP ; WB
Reactivity: Virus
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Lawrence Banks
Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-HPV18E6 [C1N1]
- Alternate name: HPV-18 E6, HPV-18 E6 protein, HPV18 E6, HPV18E6
- Cancer: Gynaecologic cancer
- Cancers detailed: Cervical
- Research fields: Cancer;Microbiology
- Clone: C1N1
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Molecular weight: 16.5 kDa
- Strain: Balb/c
- Reactivity: Virus
- Host: Mouse
- Application: ELISA ; IP ; WB
- Description: The human papilloma virus (HPV) family of DNA tumor viruses includes HPV-16 and HPV-18, which are associated with a large proportion of cervical cancer cases. HPV early proteins E6 and E7 are the major viral oncoproteins that regulate cell proliferation through the inactivation of p53 and Rb1 tumour suppressor proteins respectively. BF7 can be used for detection of HPV in cervical smears and biopsies and analysis of E6 expression in cell transformation studies.
- Immunogen: HPV18E6-beta-galactosidase fusion protein synthesized in E. coli
- Isotype: IgG
- Myeloma used: P3/NS1/1-Ag4.1
- Recommended controls: HPV infected tissue
Target Details
- Target: Human papillomavirus type 18 (HPV-18) specific epitopes on the E6 polypeptide
- Molecular weight: 16.5 kDa
- Tissue cell line specificity: HPV infected tissue
- Target background: The human papilloma virus (HPV) family of DNA tumor viruses includes HPV-16 and HPV-18, which are associated with a large proportion of cervical cancer cases. HPV early proteins E6 and E7 are the major viral oncoproteins that regulate cell proliferation through the inactivation of p53 and Rb1 tumour suppressor proteins respectively. BF7 can be used for detection of HPV in cervical smears and biopsies and analysis of E6 expression in cell transformation studies.
Applications
- Application: ELISA ; IP ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
References
- Banks et al. 1987. J Gen Virol. 68 ( Pt 5):1351-9. PMID: 3033140.
- Identification of human papillomavirus type 18 E6 polypeptide in cells derived from human cervical carcinomas.
