Anti-HLADRCD74 [By2]

HLA-DR-associated invariant chain (CD74) plays a role in antigen presentation.

Contributors

Inventor Institute
Karen Pulford University of Oxford
Cat. #: 151372
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Immunology
Application: FACS ; IHC ; IF ; IP ; WB
Target: Human Leukocyte Antigen-DR locus (HLA-DR) associated invariant chain (CD74)
Reactivity: Human
Clone: By2
Host: Mouse
Class: Monoclonal
Alternate name: CD74 Molecule; HLA-DR Antigens-Associated Invariant Chain; Gamma Chain Of Class II Antigens; Ia-Associated Invariant Chain; MHC HLA-DR Gamma Chain; DHLAG; P33; CD74 Antigen; Ia-GAMMA; HLADG
Product description: HLA-DR-associated invariant chain (CD74) plays a role in antigen presentation. In addition to its expression on antigen-presenting cells, CD74 is expressed by carcinomas of renal, lung, gastric, and thymic origin and by certain sarcomas. The restricted expression of CD74 by normal tissues and its very rapid internalization make CD74 an attractive therapeutic target for both cancer and immunologic diseases. It has also been shown to have value as a gastric carcinoma marker.
Conjugation: Unconjugated
Isotype: IgG1
Immunogen: B cell lymphoma cells
Myeloma used: P3/NS1/1-Ag4.1
Target background: HLA-DR-associated invariant chain (CD74) plays a role in antigen presentation. In addition to its expression on antigen-presenting cells, CD74 is expressed by carcinomas of renal, lung, gastric, and thymic origin and by certain sarcomas. The restricted expression of CD74 by normal tissues and its very rapid internalization make CD74 an attractive therapeutic target for both cancer and immunologic diseases. It has also been shown to have value as a gastric carcinoma marker.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Jones M et al. 1995. Workshop mAb B029 (By2) – a new B-cell marker for use in diagnostic pathology. In Schlossman SF, et al (eds) Leucocyte Typing V, Vol 1, Oxford University Press, Oxford, New York and Tokyo, p 710-11. ISBN-13: 978-0198577980

Mason D. et al (eds) CD Guide for CD74 (2002) Leucocyte Typing VII, Oxford University Press, Oxford and New York, p 825-6. ISBN-13: 978-0192632524

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