Monoclonal antibody which binds all DR and DP antigens, with use in tissue and HLA typing.
| Inventor | Institute |
|---|---|
| Walter Bodmer | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151225 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Immunology |
| Application: | ELISA ; FACS ; IHC ; WB |
| Target: | Human Leukocyte Antigen DR ? chain 1 (1st domain, monomorphic, MHC class II) |
| Reactivity: | Human |
| Clone: | DA2 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | Monoclonal antibody which binds all DR and DP antigens, with use in tissue and HLA typing. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | The membranes of LKT cells (a B lymphoblastoid cell line) |
| Immunogen Uniprot ID: | P01911 |
| Myeloma used: | P3X63Ag8 |
| Target background: | Monoclonal antibody which binds all DR and DP antigens, with use in tissue and HLA typing. Background and Research Application Human Leukocyte Antigens (HLA) are highly polymorphic proteins that are involved in the presentation of antigens to the T-cell receptor. There are two classes of HLA antigens, class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. The human MHC class II molecules bind intracellularly processed peptides and present them to T helper cells. They therefore have a critical role in the initiation of the immune response. DA2 may be used for tissue typing. This antibody will bind all DR and DP antigens except DR7, and can aid with HLA typing. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | Store at -20° C frozen. Avoid repeated freeze / thaw cycles |
| Shipping conditions: | Dry ice |
| References: |
Brodsky et al. 1980. Tissue Antigens. 16(1):30-48. PMID: 6162228. Monoclonal antibodies to HLA–DRw determinants. Brodsky et al. 1979. Immunol Rev. 47:3-61. PMID: 95015. Monoclonal antibodies for analysis of the HLA system. |
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