RNA-mediated gene silencing or RNA interference (RNAi) is a key mechanism for controlling mRNA abundance. The RNA-induced silencing complex, or RISC, is a multiprotein complex that incorporates a small interfering RNA (siRNA) or micro RNA (miRNA). Once the RISC associates with its RNA target, it is cleaved by the endonuclease Argonaute 2 (Ago2), resulting in […]
| Inventor | Institute |
|---|---|
| Martin Fritzler | University of Calgary |
| Cat. #: | 157878 |
|---|---|
| Unit size: | 100 ug |
| Research Fields: | Cell biology;Cell signaling and signal transduction |
| Application: | IF ; WB |
| Target: | GW182 |
| Reactivity: | Human ; Rabbit |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | Rinucleotide repeat containing 6A, GW1; GW182; TNRC6; CAGH26 |
|---|---|
| Product description: | RNA-mediated gene silencing or RNA interference (RNAi) is a key mechanism for controlling mRNA abundance. The RNA-induced silencing complex, or RISC, is a multiprotein complex that incorporates a small interfering RNA (siRNA) or micro RNA (miRNA). Once the RISC associates with its RNA target, it is cleaved by the endonuclease Argonaute 2 (Ago2), resulting in loss of gene function. GW182 is and RNA-binding protein involved in mRNA metabolism and it is localized to cytoplasmic storage centres known as GW bodies (GWBs). GWBs are also enriched in proteins that are involved in mRNA degradation such as Ago2, and GW182 is thought to contribute and maintain the microenvironment of the RISC. |
| Conjugation: | Unconjugated |
| Molecular weight: | 182 |
| Immunogen: | Recombinant protein |
| Target background: | RNA-mediated gene silencing or RNA interference (RNAi) is a key mechanism for controlling mRNA abundance. The RNA-induced silencing complex, or RISC, is a multiprotein complex that incorporates a small interfering RNA (siRNA) or micro RNA (miRNA). Once the RISC associates with its RNA target, it is cleaved by the endonuclease Argonaute 2 (Ago2), resulting in loss of gene function. GW182 is and RNA-binding protein involved in mRNA metabolism and it is localized to cytoplasmic storage centres known as GW bodies (GWBs). GWBs are also enriched in proteins that are involved in mRNA degradation such as Ago2, and GW182 is thought to contribute and maintain the microenvironment of the RISC. |
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| Format: | Liquid |
|---|---|
| Shipping conditions: | Dry ice |
| References: |
Gebert et al. 2019. Nat Rev Mol Cell Biol. 20(1):21-37. PMID: 30108335. Jakymiw et al. 2005. Nat Cell Biol. 7(12):1267-74. PMID: 16284622. Meister et al. 2005. Curr Biol. 15(23):2149-55. PMID: 16289642. Sen et al. 2005. Nat Cell Biol. 7(6):633-6. PMID: 15908945. Eystathioy et al. 2003. Hybrid Hybridomics. 22(2):79-86. PMID: 12831532. Eystathioy et al. 2002. Mol Biol Cell. 13(4):1338-51. PMID: 11950943. |
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