Anti-GW182 [4B6]

RNA-mediated gene silencing or RNA interference (RNAi) is a key mechanism for controlling mRNA abundance. The RNA-induced silencing complex, or RISC, is a multiprotein complex that incorporates a small interfering RNA (siRNA) or micro RNA (miRNA). Once the RISC associates with its RNA target, it is cleaved by the endonuclease Argonaute 2 (Ago2), resulting in […]

Contributors

Inventor Institute
Martin Fritzler University of Calgary
Cat. #: 157878
Unit size: 100 ug
Research Fields: Cell biology;Cell signaling and signal transduction
Application: IF ; WB
Target: GW182
Reactivity: Human ; Rabbit
Host: Mouse
Class: Monoclonal
Alternate name: Rinucleotide repeat containing 6A, GW1; GW182; TNRC6; CAGH26
Product description: RNA-mediated gene silencing or RNA interference (RNAi) is a key mechanism for controlling mRNA abundance. The RNA-induced silencing complex, or RISC, is a multiprotein complex that incorporates a small interfering RNA (siRNA) or micro RNA (miRNA). Once the RISC associates with its RNA target, it is cleaved by the endonuclease Argonaute 2 (Ago2), resulting in loss of gene function. GW182 is and RNA-binding protein involved in mRNA metabolism and it is localized to cytoplasmic storage centres known as GW bodies (GWBs). GWBs are also enriched in proteins that are involved in mRNA degradation such as Ago2, and GW182 is thought to contribute and maintain the microenvironment of the RISC.
Conjugation: Unconjugated
Molecular weight: 182
Immunogen: Recombinant protein
Target background: RNA-mediated gene silencing or RNA interference (RNAi) is a key mechanism for controlling mRNA abundance. The RNA-induced silencing complex, or RISC, is a multiprotein complex that incorporates a small interfering RNA (siRNA) or micro RNA (miRNA). Once the RISC associates with its RNA target, it is cleaved by the endonuclease Argonaute 2 (Ago2), resulting in loss of gene function. GW182 is and RNA-binding protein involved in mRNA metabolism and it is localized to cytoplasmic storage centres known as GW bodies (GWBs). GWBs are also enriched in proteins that are involved in mRNA degradation such as Ago2, and GW182 is thought to contribute and maintain the microenvironment of the RISC.
Format: Liquid
Shipping conditions: Dry ice
References:

Gebert et al. 2019. Nat Rev Mol Cell Biol. 20(1):21-37. PMID: 30108335.

Jakymiw et al. 2005. Nat Cell Biol. 7(12):1267-74. PMID: 16284622.

Meister et al. 2005. Curr Biol. 15(23):2149-55. PMID: 16289642.

Sen et al. 2005. Nat Cell Biol. 7(6):633-6. PMID: 15908945.

Eystathioy et al. 2003. Hybrid Hybridomics. 22(2):79-86. PMID: 12831532.

Eystathioy et al. 2002. Mol Biol Cell. 13(4):1338-51. PMID: 11950943.

Related Tools for Antibodies

Cat. # Tool Name
151022 Anti-IL12 [1-1A4] Key Info View Tool
151028 Anti-Cytochrome P450 2C2, 2B1/2 [h7] Key Info View Tool
151031 Anti-RuvA [RuvA 12C6] Key Info View Tool
151038 Anti-Cytochrome P450 4A2, 4A3 [Clo4] Key Info View Tool
151018 Anti-Mos [R38.1] Key Info View Tool

Tool enquiry

Please ensure you use your organisation email address rather than personal where possible, as this helps us locate your organisation in our system faster.

Please note we may take up to three days to respond to your enquiry.

CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.