Ras GTPases are frequently mutated in cancer and so far only few experimental inhibitors exist.
| Inventor | Institute |
|---|---|
| Urpo Lamminmäki | University of Turku |
| Cat. #: | 157718 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Metabolism |
| Application: | ELISA ; FACS ; IF |
| Target: | GTP |
| Reactivity: | Human |
| Class: | Recombinant |
| Product description: | GTPases are central cellular signaling proteins, which cycle between a GDP-bound inactive and a GTP-bound active conformation in a controlled manner. Ras GTPases are frequently mutated in cancer and so far only few experimental inhibitors exist. The most common methods for monitoring GTP hydrolysis rely on luminescent GDP- or GTP-analogs. (From Kopra et al Anal. Chem. 2015) |
|---|---|
| Conjugation: | Unconjugated |
| Target background: | GTPases are central cellular signaling proteins, which cycle between a GDP-bound inactive and a GTP-bound active conformation in a controlled manner. Ras GTPases are frequently mutated in cancer and so far only few experimental inhibitors exist. The most common methods for monitoring GTP hydrolysis rely on luminescent GDP- or GTP-analogs. (From Kopra et al Anal. Chem. 2015, 87, 6, 35273534) |
|---|
| Format: | Liquid |
|---|---|
| Shipping conditions: | Dry ice |
| References: |
Kopra et al. 2017. Anal Chem. 89(8):4508-4516. PMID: 28318223. Kopra et al. 2015. Anal Chem. 87(6):3527-34. PMID: 25707436. |
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