FOXP2 is a member of the forkhead transcription factor. Its mutation is associated with an inherited speech and language disorder and its biological roles have primarily been studied in neuronal tissues.
| Inventor | Institute |
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| Alison Banham | University of Oxford |
| Cat. #: | 151897 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Application: | IHC ; WB ; ChIP |
| Target: | FOXP2 |
| Reactivity: | Human ; Mouse |
| Clone: | 73A/8 |
| Class: | Monoclonal |
| Product description: | The FOXP2-73A/8 antibody detects human and murine FOXP2 and does not cross-react with other members of the FOXP family (FOXP1, FOXP3 or FOXP4). |
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| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | Bacterially expressed GST-protein containing N-terminus of FOXP2 |
| Myeloma used: | P3X63Ag8.653 |
| Target background: | FOXP2 is a member of the forkhead transcription factor. Its mutation is associated with an inherited speech and language disorder and its biological roles have primarily been studied in neuronal tissues. FOXP2 is also aberrantly expressed in abnormal plasma cells and it may play a role in the pathogenesis of multiple myeloma. |
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| Format: | Liquid |
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| Concentration: | 1mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | '-15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
FOXP2-positive diffuse large B-cell lymphomas exhibit a poor response to R-CHOP therapy and distinct biological signatures. Wong et al. 2016. Oncotarget. :. PMID: 27224915. Gascoyne et al. 2015. PLoS One. 10(6):e0128513. PMID: 26034982. The Forkhead Transcription Factor FOXP2 Is Required for Regulation of p21WAF1/CIP1 in 143B Osteosarcoma Cell Growth Arrest. Campbell et al. 2010. Br J Haematol. 149(2):221-30. PMID: 20096010. Aberrant expression of the neuronal transcription factor FOXP2 in neoplastic plasma cells. |
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