Fanconi anemia, complementation group M. Fanconi anemia-associated polypeptide of 250 kDa. ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair. Binds to ssDNA but not to dsDNA._x000D_ _x000D_ Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions.
| Inventor | Institute |
|---|---|
| Stephen West | Cancer Research UK, London Research Institute: Clare Hall Laboratories |
| Cat. #: | 151822 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Genetics |
| Application: | IF ; IP ; WB |
| Target: | Human FANCM (Fanconi anemia, complementation group M) |
| Reactivity: | Human |
| Clone: | CV5.1 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | Fanconi Anemia Complementation Group M; KIAA1596; Fanconi Anemia-Associated Polypeptide Of 25 Kda; ATP-Dependent RNA Helicase FANCM; Protein Hef Ortholog; FAAP25 |
|---|---|
| Product description: | Fanconi anemia, complementation group M. Fanconi anemia-associated polypeptide of 250 kDa. ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair. Binds to ssDNA but not to dsDNA. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Immunogen: | His-tagged denatured FANCM (aa 1507-1679) made in E.coli |
| Target background: | Fanconi anemia, complementation group M. Fanconi anemia-associated polypeptide of 250 kDa. ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair. Binds to ssDNA but not to dsDNA. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
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