| Inventor | Institute |
|---|---|
| Alison Goodall | University College London (UCL) |
| SKU: | 151529 |
|---|---|
| Product description: | The commonest severe congenital bleeding disorder in all races is haemophilia A. The characteristic defect is a lack of coagulation factor VIII:C. Factor VIII:C is a glycoprotein that functions as a cofactor for factor IXa which, in the presence of calcium and phospholipids, converts factor X to the activated form Xa. This antibody binds to human FVIII:C heavy chain and inhibits its function. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Immunogen: | Purified human factor VIII |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Cat. #: | 151529 |
|---|---|
| Unit size: | 100 ug |
| Research Fields: | Tissue-specific biology |
| Application: | IF ; Fn ; WB |
| Target: | Factor VIII |
| Reactivity: | Human |
| Clone: | RFF-VIII:c/8 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | The commonest severe congenital bleeding disorder in all races is haemophilia A. The characteristic defect is a lack of coagulation factor VIII:C. Factor VIII:C is a glycoprotein that functions as a cofactor for factor IXa which, in the presence of calcium and phospholipids, converts factor X to the activated form Xa. This antibody binds to human FVIII:C heavy chain and inhibits its function. |
|---|
| Format: | Liquid |
|---|---|
| Shipping conditions: | Dry ice |
| References: |
Takase et al. 1987. Br J Haematol. 66(4):497-502. PMID: 3117089. Production of factor VIII deficient plasma by immunodepletion using three monoclonal antibodies. Goodall et al. 1985. Thromb Haemost. 54(4):878-91. PMID: 3937279. Registry of monoclonal antibodies to factor VIII and von Willebrand factor. International Committee on Thrombosis and Haemostasis. Rotblat et al. 1985. Biochemistry. 24(16):4294-300. PMID: 2413885. Purification of human factor VIII:C and its characterization by Western blotting using monoclonal antibodies. Vehar et al. 1984. Nature. 312(5992):337-42. PMID: 6438527. Structure of human factor VIII. Rotblat et al. 1983. J Lab Clin Med. 101(5):736-46. PMID: 6403638. Monoclonal antibodies to human procoagulant factor VIII. |
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