Cat. #151159
Anti-ErbB3 [SGP1]
Cat. #: 151159
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-4 weeks
Target: ErbB3 (Her3)
Class: Monoclonal
Application: IP ; FACS ; IHC ; IF ; IP
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Bill Gullick
Institute: Imperial Cancer Research Fund
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-ErbB3 [SGP1]
- Research fields: Cancer;Cell biology;Cell signaling and signal transduction
- Clone: SGP1
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Strain: Balb/c
- Reactivity: Human
- Host: Mouse
- Application: IP ; FACS ; IHC ; IF ; IP
- Description: The EGFR family of type I growth factor receptor tyrosine kinases includes EGFR (HER1), c-erbB2 (HER2; neu), c-erbB3 (HER3) and c-erbB4 (HER4). c-erbB3 is normally found in non-dividing differentiated epithelial cells, neurones and hepatocytes. It has approximately 80% prevalence in a wide variety of tumours of the gastro-intestinal tract, and approximately 20% prevalence in breast cancer.
- Immunogen: c-erb B3 protein from transfected human kidney fibroblasts purified by wheatgerm lectin affinity chromatography
- Isotype: IgG1 kappa
- Myeloma used: NS0
Target Details
- Target: ErbB3 (Her3)
- Target background: The EGFR family of type I growth factor receptor tyrosine kinases includes EGFR (HER1), c-erbB2 (HER2; neu), c-erbB3 (HER3) and c-erbB4 (HER4). c-erbB3 is normally found in non-dividing differentiated epithelial cells, neurones and hepatocytes. It has approximately 80% prevalence in a wide variety of tumours of the gastro-intestinal tract, and approximately 20% prevalence in breast cancer.
Applications
- Application: IP ; FACS ; IHC ; IF ; IP
Handling
- Format: Liquid
- Concentration: 0.82 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Dry ice
References
- Vollmann-Zwerenz et al. 2010. Cytometry A. 77(4):387-98. PMID: 20151455.
- Multichromatic phenotyping of HER receptor coexpression in breast tumor tissue samples using flow cytometry--possibilities and limitations.
- Expression of the c-erbB-4/HER4 protein and mRNA in normal human fetal and adult tissues and in a survey of nine solid tumour types.
- Rajkumar et al. 1994. Br J Cancer. 70(3):459-65. PMID: 8080731.
- A monoclonal antibody to the human c-erbB3 protein stimulates the anchorage-independent growth of breast cancer cell lines.
