The EGFR family of type I growth factor receptor tyrosine kinases includes EGFR (HER1), c-erbB2 (HER2; neu), c-erbB3 (HER3) and c-erbB4 (HER4). c-erbB3 is normally found in non-dividing differentiated epithelial cells, neurones and hepatocytes. It has approximately 80% prevalence in a wide variety of tumours of the gastro-intestinal tract, and approximately 20% prevalence in breast […]
| Inventor | Institute |
|---|---|
| Bill Gullick | Imperial Cancer Research Fund |
| Cat. #: | 151159 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell biology;Cell signaling and signal transduction |
| Application: | IP ; FACS ; IHC ; IF ; IP |
| Target: | ErbB3 (Her3) |
| Reactivity: | Human |
| Clone: | SGP1 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | The EGFR family of type I growth factor receptor tyrosine kinases includes EGFR (HER1), c-erbB2 (HER2; neu), c-erbB3 (HER3) and c-erbB4 (HER4). c-erbB3 is normally found in non-dividing differentiated epithelial cells, neurones and hepatocytes. It has approximately 80% prevalence in a wide variety of tumours of the gastro-intestinal tract, and approximately 20% prevalence in breast cancer. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Immunogen: | c-erb B3 protein from transfected human kidney fibroblasts purified by wheatgerm lectin affinity chromatography |
| Myeloma used: | NS0 |
| Target background: | The EGFR family of type I growth factor receptor tyrosine kinases includes EGFR (HER1), c-erbB2 (HER2; neu), c-erbB3 (HER3) and c-erbB4 (HER4). c-erbB3 is normally found in non-dividing differentiated epithelial cells, neurones and hepatocytes. It has approximately 80% prevalence in a wide variety of tumours of the gastro-intestinal tract, and approximately 20% prevalence in breast cancer. |
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| Format: | Liquid |
|---|---|
| Concentration: | 0.82 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Vollmann-Zwerenz et al. 2010. Cytometry A. 77(4):387-98. PMID: 20151455. Multichromatic phenotyping of HER receptor coexpression in breast tumor tissue samples using flow cytometry–possibilities and limitations. Expression of the c-erbB-4/HER4 protein and mRNA in normal human fetal and adult tissues and in a survey of nine solid tumour types. Rajkumar et al. 1994. Br J Cancer. 70(3):459-65. PMID: 8080731. A monoclonal antibody to the human c-erbB3 protein stimulates the anchorage-independent growth of breast cancer cell lines. |
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