Anti-DNA [m165-49]

Monoclonal anti-DNA antibodies were generated from a spontaneous mouse model of Systemic Lupus Erythematosus (SLE) (NZB x NZW)F1 using standard methodologies for the generation of B-cell hybridomas. The mice spontaneously developed anti-DNA antibodies that contributed to SLE disease. The mice were neither immunized nor stimulated non-specifically. Hybridomas derived from these autoimmune mice provide the opportunity […]

Contributors

Inventor Institute
Tony Marion The University of Tennessee Health Science Center (UTHSC)
Cat. #: 157830
Unit size: 100 ug
Research Fields: Immunology
Application: ELISA
Target: ssDNA and/or dsDNA
Host: Mouse
Class: Monoclonal
Product description: Monoclonal anti-DNA antibodies were generated from a spontaneous mouse model of Systemic Lupus Erythematosus (SLE) (NZB x NZW)F1 using standard methodologies for the generation of B-cell hybridomas. The mice spontaneously developed anti-DNA antibodies that contributed to SLE disease. The mice were neither immunized nor stimulated non-specifically. Hybridomas derived from these autoimmune mice provide the opportunity to analyse the structure, function, and biology of autoantibodies important to understanding their contribution to the pathogenesis of SLE. Table 1 provides a summary of the variable region structures and DNA specificity for the monoclonal anti-DNA autoantibodies generated.
Conjugation: Unconjugated
Isotype: IgG2a
Immunogen Uniprot ID: N/A
Target background: Monoclonal anti-DNA antibodies were generated from a spontaneous mouse model of Systemic Lupus Erythematosus (SLE) (NZB x NZW)F1 using standard methodologies for the generation of B-cell hybridomas. The mice spontaneously developed anti-DNA antibodies that contributed to SLE disease. The mice were neither immunized nor stimulated non-specifically. Hybridomas derived from these autoimmune mice provide the opportunity to analyse the structure, function, and biology of autoantibodies important to understanding their contribution to the pathogenesis of SLE. Table 1 provides a summary of the variable region structures and DNA specificity for the monoclonal anti-DNA autoantibodies generated.
Format: Liquid
Shipping conditions: Dry ice
References:

Marion et al. 1997. Methods. 11(1):3-11. PMID: 8990083.

Tillman et al. 1992. J Exp Med. 176(3):761-79. PMID: 1512540.

Marion et al. 1982. J Immunol. 128(2):668-74. PMID: 7198664.

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