Cat. #151239
Anti-DMC1 [2H12/4] mAb
Cat. #: 151239
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-4 weeks
Target: DMC1
Class: Monoclonal
Application: FACS ; IHC ; IF ; IP ; WB
Reactivity: Bovine ; Human ; Mouse
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Stephen West
Institute: Cancer Research UK, London Research Institute: Clare Hall Laboratories
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-DMC1 [2H12/4] mAb
- Alternate name: Disrupted meiotic cDNA 1 homolog, Disrupted meiotic cDNA 1, yeast homolog of, dJ199H16.1, DMC 1, DMC1, DMC1 dosage suppressor of mck1 homolog, DMC1 dosage suppressor of mck1 homolog meiosis specific homologous recombination (yeast), DMC1 homologue
- Research fields: Genetics
- Clone: 2H12/4
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Strain: Balb/c
- Reactivity: Bovine ; Human ; Mouse
- Host: Mouse
- Application: FACS ; IHC ; IF ; IP ; WB
- Description: DMC1 is a meiosis-specific homologue of RecA/RAD51 and is an essential component of the meiotic recombination machinery in yeast and higher eukaryotes.
- Immunogen: human DMC1 protein (expressed as 6xHis fusion in E. coli and band cut out of gel of insoluble pelet)
- Isotype: IgG2a
- Myeloma used: Sp2/0-Ag14
Target Details
- Target: DMC1
- Target background: DMC1 is a meiosis-specific homologue of RecA/RAD51 and is an essential component of the meiotic recombination machinery in yeast and higher eukaryotes.
Applications
- Application: FACS ; IHC ; IF ; IP ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Dry ice
References
- Lin et al. 2013. PLoS Genet. 9(5):e1003516. PMID: 23717213.
- Ikbkap/Elp1 deficiency causes male infertility by disrupting meiotic progression.
- Erenpreisa et al. 2009. Exp Cell Res. 315(15):2593-603. PMID: 19463812.
- The role of meiotic cohesin REC8 in chromosome segregation in gamma irradiation-induced endopolyploid tumour cells.
- Masson et al. 1999. EMBO J. 18(22):6552-60. PMID: 10562567.
- The meiosis-specific recombinase hDmc1 forms ring structures and interacts with hRad51.
