#152652

Anti-Delta10 [1A9]

Cat. #152652

Anti-Delta10 [1A9]

Cat. #: 152652

Unit size: 100 ug

Availability: 3-5 days

Target: S protein of the SARS coronavirus

Class: Monoclonal

Application: FACS ; Fn ; WB

Reactivity: Virus

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Institute: A*STAR Accelerate Technologies Pte Ltd

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: Anti-Delta10 [1A9]
  • Clone: 1A9
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Reactivity: Virus
  • Host: Mouse
  • Application: FACS ; Fn ; WB
  • Description: Severe acute respiratory syndrome coronavirus (SARS-CoV) genome encodes for four structural proteins, namely nucleocaspid (N), spike (S), membrane (M) and envelope (E). The S protein, which forms morphologically characteristic projections on the virion surface, is responsible for binding to cellular receptor and mediating the fusion between viral and cellular membranes. Both of these processes are critical for virus entry into host cells. The SΔ10 is a fragment containing residues from 1029 to 1129 of the S protein, which is a domain that is crucial for the fusion process.
  • Immunogen: GST-S?10 fusion protein
  • Isotype: IgG1 kappa
  • Myeloma used: Sp2/0-Ag14
  • Recommended controls: SARS-CoV-infected Vero E6 cells

Target Details

  • Target: S protein of the SARS coronavirus
  • Target background: Severe acute respiratory syndrome coronavirus (SARS-CoV) genome encodes for four structural proteins, namely nucleocaspid (N), spike (S), membrane (M) and envelope (E). The S protein, which forms morphologically characteristic projections on the virion surface, is responsible for binding to cellular receptor and mediating the fusion between viral and cellular membranes. Both of these processes are critical for virus entry into host cells. The SΔ10 is a fragment containing residues from 1029 to 1129 of the S protein, which is a domain that is crucial for the fusion process.

Applications

  • Application: FACS ; Fn ; WB

Handling

  • Format: Liquid
  • Concentration: 1mg/ml
  • Unit size: 100 ug
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15° C to -25° C
  • Shipping conditions: Shipping at 4° C

References

  • Ng et al. 2014. PLoS One. 9(7):e102415. PMID: 25019613.
  • Substitution at aspartic acid 1128 in the SARS coronavirus spike glycoprotein mediates escape from a S2 domain-targeting neutralizing monoclonal antibody.
  • Lip et al. 2006. J Virol. 80(2):941-50. PMID: 16378996.
  • Monoclonal antibodies targeting the HR2 domain and the region immediately upstream of the HR2 of the S protein neutralize in vitro infection of severe acute respiratory syndrome coronavirus.