Anti-Delta10 [1A9]

Severe acute respiratory syndrome coronavirus (SARS-CoV) genome encodes for four structural proteins, namely nucleocaspid (N), spike (S), membrane (M) and envelope (E). The S protein, which forms morphologically characteristic projections on the virion surface, is responsible for binding to cellular receptor and mediating the fusion between viral and cellular membranes. Both of these processes are […]

Contributors

Institute
A*STAR Accelerate Technologies Pte Ltd
Cat. #: 152652
Unit size: 100 ug
Research Fields: Microbiology
Application: FACS ; Fn ; WB
Target: S protein of the SARS coronavirus
Reactivity: Virus
Clone: 1A9
Host: Mouse
Class: Monoclonal
Product description: Severe acute respiratory syndrome coronavirus (SARS-CoV) genome encodes for four structural proteins, namely nucleocaspid (N), spike (S), membrane (M) and envelope (E). The S protein, which forms morphologically characteristic projections on the virion surface, is responsible for binding to cellular receptor and mediating the fusion between viral and cellular membranes. Both of these processes are critical for virus entry into host cells. The SΔ10 is a fragment containing residues from 1029 to 1129 of the S protein, which is a domain that is crucial for the fusion process.
Conjugation: Unconjugated
Isotype: IgG1 kappa
Immunogen: GST-S?10 fusion protein
Myeloma used: Sp2/0-Ag14
Target background: Severe acute respiratory syndrome coronavirus (SARS-CoV) genome encodes for four structural proteins, namely nucleocaspid (N), spike (S), membrane (M) and envelope (E). The S protein, which forms morphologically characteristic projections on the virion surface, is responsible for binding to cellular receptor and mediating the fusion between viral and cellular membranes. Both of these processes are critical for virus entry into host cells. The SΔ10 is a fragment containing residues from 1029 to 1129 of the S protein, which is a domain that is crucial for the fusion process.
Format: Liquid
Concentration: 1mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Ng et al. 2014. PLoS One. 9(7):e102415. PMID: 25019613.

Substitution at aspartic acid 1128 in the SARS coronavirus spike glycoprotein mediates escape from a S2 domain-targeting neutralizing monoclonal antibody.

Lip et al. 2006. J Virol. 80(2):941-50. PMID: 16378996.

Monoclonal antibodies targeting the HR2 domain and the region immediately upstream of the HR2 of the S protein neutralize in vitro infection of severe acute respiratory syndrome coronavirus.

Images

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Western blotting on lysates prepared from SARS-CoV-infected Vero E6 cells (+) using anti-S?10 [1A9]. A lysate from mock Vero E6 cells is included as a negative control using anti-S?10 [1A9].

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