CYP1A2 is an aryl hydrocarbon hydroxylase involved in the metabolism of endogenous compounds and xenobiotics. It is one of the major drug metabolising enzymes in humans.
| Inventor | Institute |
|---|---|
| Roland Wolf | Syngenta Crop |
| Cat. #: | 151201 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell signaling and signal transduction;Metabolism;Tissue-specific biology |
| Application: | ELISA ; IHC ; IF ; WB |
| Target: | Cytochrome P450 1A2, CYP1A2 |
| Reactivity: | Human ; Mouse ; Rat |
| Clone: | D15 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | In animals, P450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs. The four major families involved in drug metabolism are CYP 1,2,3, and 4. CYP1A2 is an aryl hydrocarbon hydroxylase involved in the metabolism of endogenous compounds and xenobiotics. It is one of the major drug metabolising enzymes in humans. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1k |
| Molecular weight: | 52 kDa |
| Immunogen: | MC1a (Preparation C31B4, rat liver cytochrome P4501A2) |
| Target background: | In animals, P450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs. The four major families involved in drug metabolism are CYP 1,2,3, and 4. CYP1A2 is an aryl hydrocarbon hydroxylase involved in the metabolism of endogenous compounds and xenobiotics. It is one of the major drug metabolising enzymes in humans. |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Getachew et al. 2010. Biochem Pharmacol. 79(9):1363-71. PMID: 20036646. Seibert et al. 2009. J Proteome Res. 8(4):1672-81. PMID: 19714871. Lane et al. 2007. Mol Cell Proteomics. 6(6):953-62. PMID: 17296599. |
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