Monoclonal antibody directed against a shared epitope between CEACAM3 and 5.
| Inventor | Institute |
|---|---|
| Bernhard B. Singer | LeukoCom |
| Cat. #: | 153326 |
|---|---|
| Unit size: | 100 ug |
| Research Fields: | Immunology |
| Application: | ELISA ; FACS ; IP ; WB |
| Target: | CEACAM3/5, CD66d, CD66e |
| Reactivity: | Human |
| Clone: | 308/3-3 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | CD66d, CD66e |
|---|---|
| Product description: | Monoclonal antibody directed against a shared epitope between CEACAM3 and 5. Background and Research Application Carcinoembryonic antigen-related cell adhesion molecule (CEACAM) 3/5 belong to the immunoglobulin superfamily. These proteins contain 1 Ig-like V-type (immunoglobulin-like) domain and the cytosolic domain is involved in S100A9 interaction. CEACAMs are reported to participate in diverse physiological processes, including cell adhesion, differentiation, proliferation, and survival, as well as in carcinogenesis and bacterial pathogenesis. CEACAM molecules play a crucial role within the innate immune system, via phagocytosis and pathogen clearance. This antibody reacts with an antigen epitope shared by CEACAM 3 and 5. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Molecular weight: | 30, 180 |
| Immunogen: | Recombinant soluble human CEACAM3-Fc produced in HEK293 cells |
| Immunogen Uniprot ID: | P40198 |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Target background: | Monoclonal antibody directed against a shared epitope between CEACAM3 and 5. Background and Research Application Carcinoembryonic antigen-related cell adhesion molecule (CEACAM) 3/5 belong to the immunoglobulin superfamily. These proteins contain 1 Ig-like V-type (immunoglobulin-like) domain and the cytosolic domain is involved in S100A9 interaction. CEACAMs are reported to participate in diverse physiological processes, including cell adhesion, differentiation, proliferation, and survival, as well as in carcinogenesis and bacterial pathogenesis. CEACAM molecules play a crucial role within the innate immune system, via phagocytosis and pathogen clearance. This antibody reacts with an antigen epitope shared by CEACAM 3 and 5. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
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