Cat. #153218
Anti-CD74 [BU45]
Cat. #: 153218
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-4 weeks
Target: CD74
Class: Monoclonal
Application: IHC
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Margaret Goodall
Institute: University of Birmingham
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-CD74 [BU45]
- Alternate name: HLA class II histocompatibility antigen gamma chain; HLA-DR antigens-associated invariant chain; Cluster of Differentiation 74
- Cancer: Genitourinary cancer
- Cancers detailed: Bladder
- Research fields: Immunology
- Clone: BU45
- Tool sub type: Primary antibody
- Class: Monoclonal
- Purpose: Marker
- Conjugation: Unconjugated
- Strain: Balb/c
- Reactivity: Human
- Host: Mouse
- Application: IHC
- Description: CD74 is expressed primarily by antigen presenting cells such as B lymphocytes , macrophages and monocytes together, with many epithelialcells. CD74 may exist in different isoforms ranging in size from 33 to 41kDa, depending on genetic splicing. CD74 is a type II transmembrane protein which binds to the binding groove of nacent MHC class II alpha/beta heterodimers preventing their premature association with endogenous polypeptides. The half life of CD74 on the cell surface is relatively short ...
- Immunogen: B lymphoblastoid cell line: HFB1
- Isotype: IgG1
Target Details
- Target: CD74
- Tissue cell line specificity: Mouse
- Target background: CD74 is expressed primarily by antigen presenting cells such as B lymphocytes , macrophages and monocytes together, with many epithelialcells. CD74 may exist in different isoforms ranging in size from 33 to 41kDa, depending on genetic splicing. CD74 is a type II transmembrane protein which binds to the binding groove of nacent MHC class II alpha/beta heterodimers preventing their premature association with endogenous polypeptides. The half life of CD74 on the cell surface is relatively short ...
Applications
- Application: IHC
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
References
- Leucocyte Typing IV, (1989): edited by W. Knapp, OUP, Oxford.
- Leucocyte Typing V, (1995): edited by S.F. Schlossman, OUP, Oxford.
- Wraight et al. 1990. J Biol Chem. 265(10):5787-92. PMID: 1690714.
- Human major histocompatibility complex class II invariant chain is expressed on the cell surface.
