#152487

Anti-CD49e [SNAKA51]

Cat. #152487

Anti-CD49e [SNAKA51]

Cat. #: 152487

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 3-4 weeks

Target: Integrin alpha5 (CD49e)

Class: Monoclonal

Application: IF ; Fn ; WB

Reactivity: Human

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Martin Humphries

Institute: University of Manchester

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: Anti-CD49e [SNAKA51]
  • Alternate name: Integrin Subunit Alpha 5; Fibronectin Receptor Subunit Alpha; CD49 Antigen-Like Family Member E; Integrin Alpha-F; VLA-5; FNRA; Very Late Activation Protein 5; Alpha Subunit; Fibronectin Receptor; Alpha Polypeptide; Fibronectin Receptor; Alpha Subunit; Fibronectin Receptor; Alpha Polypeptide; Integrin Alpha; CD49e Antigen; CD49e; VLA5A
  • Clone: SNAKA51
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Purpose: Marker
  • Conjugation: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: IF ; Fn ; WB
  • Description: CD49e is the integrin alpha 5 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 5 undergoes post translational cleavage in the extracellular domain to yield disulfide linked light and heavy chains that join with beta 1 to form a fibronectin receptor that is known variously: in lymphocytes as very late (activation) antigen 5 (VLA5); in platelets as glycoprotein IcIIa; and in fibroblasts as extracellular matrix receptor 6 (ECM...
  • Immunogen: Whole cells corresponding to human Integrin alpha5.
  • Isotype: IgG2a kappa
  • Myeloma used: P3X63Ag8.653
  • Recommended controls: HeLa cells

Target Details

  • Target: Integrin alpha5 (CD49e)
  • Tissue cell line specificity: Mouse
  • Target background: CD49e is the integrin alpha 5 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 5 undergoes post translational cleavage in the extracellular domain to yield disulfide linked light and heavy chains that join with beta 1 to form a fibronectin receptor that is known variously: in lymphocytes as very late (activation) antigen 5 (VLA5); in platelets as glycoprotein IcIIa; and in fibroblasts as extracellular matrix receptor 6 (ECM...

Applications

  • Application: IF ; Fn ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Unit size: 100 ug
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15° C to -25° C
  • Shipping conditions: Shipping at 4° C

References

  • Valdembri et al. 2009. PLoS Biol. 7(1):e25. PMID: 19175293.
  • Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells.
  • Clark et al. 2005. J Cell Sci. 118(Pt 2):291-300. PMID: 15615773.
  • A specific alpha5beta1-integrin conformation promotes directional integrin translocation and fibronectin matrix formation.