Antibody was also found bound to Collagen III receptors of freshly derived and cultured human cells for including a wide variety of nucleated cells: lymphocytes, monocytes, granulocytes, epithelial cells, and fibroblasts.
| Inventor | Institute |
|---|---|
| Elizabeth A. Wayner, William Carter | Fred Hutchinson Cancer Center |
| Cat. #: | 161651 |
|---|---|
| Tool sub type: | Primary antibody |
| Research Fields: | Cell biology |
| Application: | FACS, Immunohistochemistry, Immunoprecipitation, Western Blot |
| Target: | CD44(CRIII) |
| Reactivity: | Human, Macaques |
| Clone: | P1G12 |
| Host: | Mouse |
| Class: | Monoclonal |
| Primary citation: | Wayner et al.1987. J. Cell Biol. 105(4):1873-84. PMID: 2822727 |
| Product description: | MoAb was developed to identify four distinct classes (I, II, III, IV) of cell surface receptors for native collagen. MoAb P1GI2 either increased cell adhesion to collagen or had no effect. It stimulated attachment of collagen to class III receptors and cell adhesion and shows a preferential association with cytoskeletal components. |
|---|---|
| Isotype: | IgG1 |
| Molecular weight: | 90-95kDa |
| Immunogen: | HT1080 human fibrosarcoma cell line |
| Target background: | CD44 is a hyaluronan cell adhesion molecule (HCAM), GP90 lymphocyte homing receptor, and class III collagen receptor (CRIII). Membrane glycoprotein termed class III( Anyibody P1G12) binds type I and VI collagen but not fibronectin. |
|---|
| Storage conditions: | For immediate use, short term storage at 4°C up to two weeks is recommended. For long term storage, divide the solution into volumes of no less than 20 ul for freezing at -20°C or -80°C. The small volume aliquot should provide sufficient reagent for short term use. Freeze-thaw cycles should be avoided. |
|---|---|
| Shipping conditions: | Dry ice |
| References: |
Wayner et al.1987. J. Cell Biol. 105(4):1873-84. PMID: 2822727 |
|---|
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