The CD3-epsilon polypeptide together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex.
| Institute |
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| Netherlands Cancer Institute |
| SKU: | 154754 |
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| Product description: | The CD3-epsilon polypeptide together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause severe immunodeficiency. |
| Alternate name: | CD3E; T-Cell Surface Glycoprotein CD3 Epsilon Chain |
| Conjugation: | Unconjugated |
| Isotype: | IgG2b |
| Immunogen: | Human cytotoxic T-lymphocytes |
| Myeloma used: | Sp2/0-Ag14 |
| Cat. #: | 154754 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell signaling and signal transduction;Immunology |
| Application: | FACS ; IP |
| Target: | CD3 e |
| Reactivity: | Human |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | The CD3-epsilon polypeptide together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause severe immunodeficiency. |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Spits et al. 1983. Hybridoma. 2(4):423-37. PMID: 6332061. |
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