Anti-CD27 [LG8A6]

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Name: Anti-CD27 [LG8A6]
• Alternate name: Tumor Necrosis Factor Receptor Superfamily, Member 7; TNFRSF7
• Research fields: Apoptosis and autophagy;Cell signaling and signal transduction;Immunology
• Tool sub type: Primary antibody
• Class: Monoclonal
• Conjugation: Unconjugated
• Molecular weight: 60 kDa
• Strain: Armenian
• Reactivity: Human ; Mouse
• Host: Hamster
• Application: ELISA ; FACS ; IHC ; IP
• Description: CD27 is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-Î?B and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signalling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.
• Immunogen: Armenian hamster fibroblasts transfected with the mouse CD27 DNA.
• Isotype: IgG
• Myeloma used: Sp2/0-Ag14

Target Details

• Target: CD27
• Molecular weight: 60 kDa
• Target background: CD27 is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-B and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signalling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.

Applications

• Application: ELISA ; FACS ; IHC ; IP

Handling

• Format: Liquid
• Concentration: 0.9-1.1 mg/ml
• Unit size: 100 ug
• Storage buffer: PBS with 0.02% azide
• Storage conditions: -15° C to -25° C
• Shipping conditions: Shipping at 4° C

References

• Hendriks et al. 2000. Nat Immunol. 1(5):433-40. PMID: 11062504.
• Gravestein et al. 1996. J Exp Med. 184(2):675-85. PMID: 8760821.
• Gravestein et al. 1995. Int Immunol. 7(4):551-7. PMID: 7547681.