Anti-c-Met [17]

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Name: Anti-c-Met [17]
• Research fields: Cancer;Cell signaling and signal transduction;Genetics
• Clone: 17
• Tool sub type: Primary antibody
• Class: Monoclonal
• Conjugation: Unconjugated
• Reactivity: Human
• Host: Mouse
• Application: FACS ; IF ; IP ; WB
• Description: c-Met is a tyrosine receptor kinase which is activated by its ligand, the hepatocyte growth factor. Activation of c-Met leads to a wide spectrum of biological activities such as motility, angiogenesis, morphogenesis, cell survival and cell regeneration. c-Met is abnormally activated in many tumour types. Aberrant c-Met activation was found to induce tumour development, tumour cell migration and invasion, and the worst and final step in cancer progression, metastasis.
• Immunogen: Bacterially expressed human c-Met alpha chain
• Isotype: IgG1 kappa
• Myeloma used: Sp2/0-Ag14
• Recommended controls: SNU-5, U-87MG and MKN45 cells (negative control: T47D cells)

Target Details

• Target: c-Met, cMet
• Tissue cell line specificity: SNU-5, U-87MG and MKN45 cells (negative control: T47D cells)
• Target background: c-Met is a tyrosine receptor kinase which is activated by its ligand, the hepatocyte growth factor. Activation of c-Met leads to a wide spectrum of biological activities such as motility, angiogenesis, morphogenesis, cell survival and cell regeneration. c-Met is abnormally activated in many tumour types. Aberrant c-Met activation was found to induce tumour development, tumour cell migration and invasion, and the worst and final step in cancer progression, metastasis.

Applications

• Application: FACS ; IF ; IP ; WB

Handling

• Format: Liquid
• Concentration: 1 mg/ml
• Unit size: 100 ug
• Storage buffer: PBS with 0.02% azide
• Storage conditions: -15° C to -25° C
• Shipping conditions: Dry ice

Related Tools

• Related tools: Anti-c-Met 12.1 ; Anti-c-Met 13 ; Anti-c-Met 8

References

• Wong et al. 2013. Oncotarget. 4(7):1019-36. PMID: 23859937.
• Anti-c-Met antibodies recognising a temperature sensitive epitope, inhibit cell growth.