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× Expression of MUC1 in non-neoplastic bladder urothelium; non-invasive papillary urothelial carcinoma; urothelial carcinoma in situ and invasive high grade urothelial carcinoma. Bladder tumor tissue sections or spots were probed with anti-MUC1 mAb (HMFG2) after non-specific blocking with horse serum. All sections were examined under microscope and the immunoreactivity was evaluated by reddish brown staining. Representative photomicrographs are shown for MUC1 stained non-neoplastic bladder urothelium (A&B); low-grade papillary carcinoma (C); bladder carcinoma in situ (D); and high grade invasive cancer (E&F). In normal bladder urothelium; MUC1 expression was restricted to umbrella cells (shown by arrowhead in panel A and the magnified inset) in majority of samples. In some samples; a sheath of MUC1 mucin was observed over urothelium (arrow in 1B). In low-grade papillary carcinoma; intense staining of MUC1 was observed on the luminal surface of the urothelium and lower intensity of staining was observed in the other layers of urothelium (C). In urothelial carcinoma in situ; MUC1 expression was observed in all the layers of urothelium; however; staining was comparatively stronger in cells closer to the luminal border (D). In invasive high grade urothelial carcinoma; MUC1 staining was observed in cells invading singly (E) or as small groups within the lamina propria (F). Taken from PLoS One. 2014 Mar 26;9(3) Anti-MUC1 [HMFG2]

Target: Mucin1 (MUC1)

Sub-type: Primary antibody

Host: Mouse

Application: ELISA ; FACS ; IHC ; IP ; Fn ; WB

Cat. #152814

 £300.00
£300.00

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