ELISA showing equivalence in performance between anti-MUC1; Recombinant [HMFG2] ("recombinant HMFG2") and Anti-MUC1 [HMFG2] ("purified HMFG2"). ELISA was performed on a 60mer peptide which consists of 3 tandem repeats of MUC1. The secondary anti-mouse antibody was HRP linked and the binding identified with a coloured substrate; O-phenylenediamine. Data kindly provided by Dr. Joy Burchell and Prof. Joyce Taylor-Papadimitriou

Anti-MUC1 [HMFG2] Product

Recombinant antibody which detects several glycoforms of MUC1, a marker of breast cancer.

Expression of MUC1 in non-neoplastic bladder urothelium; non-invasive papillary urothelial carcinoma; urothelial carcinoma in situ and invasive high grade urothelial carcinoma. Bladder tumor tissue sections or spots were probed with anti-MUC1 mAb (HMFG2) after non-specific blocking with horse serum. All sections were examined under microscope and the immunoreactivity was evaluated by reddish brown staining. Representative photomicrographs are shown for MUC1 stained non-neoplastic bladder urothelium (A&B); low-grade papillary carcinoma (C); bladder carcinoma in situ (D); and high grade invasive cancer (E&F). In normal bladder urothelium; MUC1 expression was restricted to umbrella cells (shown by arrowhead in panel A and the magnified inset) in majority of samples. In some samples; a sheath of MUC1 mucin was observed over urothelium (arrow in 1B). In low-grade papillary carcinoma; intense staining of MUC1 was observed on the luminal surface of the urothelium and lower intensity of staining was observed in the other layers of urothelium (C). In urothelial carcinoma in situ; MUC1 expression was observed in all the layers of urothelium; however; staining was comparatively stronger in cells closer to the luminal border (D). In invasive high grade urothelial carcinoma; MUC1 staining was observed in cells invading singly (E) or as small groups within the lamina propria (F). Taken from PLoS One. 2014 Mar 26;9(3)

Anti-MUC1 [HMFG2] Product

Monoclonal antibody which detects several glycoforms of MUC1, a marker of breast cancer.

Anti-MUC1 [HMFG1] Product

Mucin-1 ( MUC1) is a membrane protein present on normal human breast epithelial cells and cell lines derived from breast carcinomas. Human MUC1 is also localised on the surface of […]

Breast cancer Page

[…] PDX models by grafting tumour tissues from a patient into immunodeficient mice, created with Biorender. MUC1 mouse model Tumour associated antigen, MUC1 is aberrantly overexpressed in 90% of human breast […]

Anti-MUC1 [SM3] Product

SM3 antibody recognises this under-glycosylated form of MUC1 and is therefore tunour specific and may be relevant for breast cancer therapy. SM3 also detects MUC1 within colon and ovarian cancer […]

Anti-MUC1 [C789] Product

At an early stage disease, only 21% of patients exhibit high MUC1/CA 15-3 levels, that is why CA 15-3 is not a useful screening test.

Anti-MUC1 [C595 (NCRC48)] Product

MUC1/CA 15-3 is used as a serological clinical marker of breast cancer to monitor response to breast cancer treatment and disease recurrence. Most antibodies target the highly immunodominant core […]

Anti-CD227 (MUC1) [140C1] Product

Overexpression of MUC1 is often associated with colon, breast, ovarian, lung and pancreatic cancers

Anti-CD227 (MUC1) [139H2] Product

MUC1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain.

E3 STn Cell Line Product

The E3 STn Cell Line is a mouse mammary carcinoma cell line E3 which expresses human MUC1 and Sialyl-Tn.