Cat. #160586
Anti-hEMILIN1 [hEMIL1]
Cat. #: 160586
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 10-12 weeks
Target: hEMILIN1
Class: Monoclonal
Application: ELISA ; IHC ; IF ; IP ; Fn ; WB
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Alfonso Colombatti ; Maurizio Mongiat ; Paola Spessotto ; Roberto Doliana ; Maria Teresa Mucignat
Institute: National Cancer Institute CRO - Aviano
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-hEMILIN1 [hEMIL1]
- Research fields: Cell biology;Cell signaling and signal transduction
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: ELISA ; IHC ; IF ; IP ; Fn ; WB
- Description: Emilin-1 (Elastin Microfibril Interface Located proteIN) is an extracellular matrix glycoprotein. It is part of a protein family which have been shown to be expressed in smooth muscle and other mesenchymal tissues and is localized at the proximity of elastin and microfibrils. Emilin-1 exerts an important role in lymphatic system, being a crucial structural molecule that regulates the formation of lymphatic capillaries and collectors. Emilin-1 through the interaction with the ÄÂ?4ÄÂ?1 integrin via the C-terminal gC1q domain exerts a negative effect on proliferation. It binds pro-TGFÄÂ? preventing its maturation to mature TGFÄÂ? in the extracellular space, therefore influencing the regulation of blood and lymph vessels formation and maintenance.
- Immunogen: Recombinant human Emilin-1 as immunizing antigen; Balb/c mice as host
- Recommended controls: IgG2a kappa
Target Details
- Target: hEMILIN1
- Tissue cell line specificity: IgG2a kappa
- Target background: Emilin-1 (Elastin Microfibril Interface Located proteIN) is an extracellular matrix glycoprotein. It is part of a protein family which have been shown to be expressed in smooth muscle and other mesenchymal tissues and is localized at the proximity of elastin and microfibrils. Emilin-1 exerts an important role in lymphatic system, being a crucial structural molecule that regulates the formation of lymphatic capillaries and collectors. Emilin-1 through the interaction with the a4?1 integrin via...
Applications
- Application: ELISA ; IHC ; IF ; IP ; Fn ; WB
Handling
- Format: Liquid
- Unit size: 100 ug
- Storage conditions: Store at 2 - 8° C or aliquots at -20° C. Avoid repeated freeze-thaw cycles
- Shipping conditions: Dry ice
Related Tools
- Related tools: Anti-hEMILIN2 [hEMIL2] monoclonal antibody ; Anti-mMMRN2 [mMMRN2] monoclonal antibody ; Anti-mEMILIN1 [mEMIL] monoclonal antibody
References
- Capuano et al. 2016. Hum Mutat. 37(1):84-97. PMID: 26462740.
- Pivetta et al. 2014. Matrix Biol. 34:22-32. PMID: 24513040.
- Danussi et al. 2013. Mol Cell Biol. 33(22):4381-94. PMID: 24019067.
- Danussi et al. 2012. Cancer Prev Res (Phila). 5(9):1131-43. PMID: 22827975.
- Danussi et al. 2011. J Cell Biol. 195(1):131-45. PMID: 21949412.
- Danussi et al. 2008. Mol Cell Biol. 28(12):4026-39. PMID: 18411305.
- Spessotto et al. 2006. J Cell Sci. 119(Pt 21):4574-84. PMID: 17074837.
- Zacchigna et a...
