Phosphatidylinositol-4-phosphate 5-kinase inhibitor PIP5K Small Molecule (Tool Compound)

A selective inhibitor of phosphatidylinositol-4-phosphate 5-kinase (PIP5K) which demonstrates anti-cancer activity.

Contributors

Inventor Institute
Martin Swarbrick Cancer Research Technology AstraZeneca Metabolism Alliance Team
Cat. #: 160406
Tool sub type: Inhibitor
Research Fields: Cancer
Purpose: Inhibitor
Alternate name: Synonyms for Phosphatidylinositol-4-phosphate 5-kinase: PIKFYVE, Phosphoinositide Kinase, FYVE Finger Containing Phosphatidylinositol-3-Phosphate/Phosphatidylinositol 5-Kinase Type III, Phosphatidylinositol 3-Phosphate 5-Kinase Type III, Type III PIP Kinase, PIPkin-III, PIP5K3, FYVE Finger-Containing Phosphoinositide Kinase 4, 1-Phosphatidylinositol-3-Phosphate 5-Kinase, Phosphatidylinositol 3-Phosphate 5-Kinase, Zinc Finger FYVE Domain Containing, Epididymis Luminal Protein 37, FYVE Domain Containing 29, KIAA981, ZFYVE29, PIKfyve, HEL37, PIP5K, FAB1, CFD
Additional notes: Relevant Indications: PI3K, PLC, Wnt, Fc-receptor, BAF Negative Control Available: No The compounds are made up to 12mM stock concentration in DMSO. The final concentration of DMSO when treating cells should be less than 1%.
Selectivity: PI4KCA IC50: 20.9 ÂľM PI4KCB IC50: 5.99 ÂľM PI3KÎą IC50: 34.6 ÂľM
Primary target: Phosphatidylinositol-4-phosphate 5-kinase (PIP5K)
Shipping conditions: Dry Ice
Solubility: 15 ľM (Aqueous)
References:

Andrews et al. 2014. Eur. J. Cancer. 50(6):91

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