Sox10iCre/+; Myrffl/fl mouse

Deymelination restricted to CNS & lack of remyelination.

Contributors

Inventor Institute
Ben Emery Oregon Health & Science University
Cat. #: 157783
Research Fields: Neurobiology
Target: Myrf (myelin regulatory factor)
disease: Tamoxifen activated inactivation of Myrf for demyelination of throughout the CNS
Model: Conditional KO
Strain: C57BL/6
Phenotype: Demyelination of CNS
Product description: Deymelination restricted to CNS & lack of remyelination.
Conditional: Yes
Conditional description: inducible demyelination without remyelination
Genetic background: MyrfFl/Fl mouse line crossed with a Sox10-CreERT transgenic line expressing tomoxifen inducible Cre recombinase in the oligodendrocyte lineage.
Shipping conditions: Embryo/Spermatoza- Dry Ice
References:

30996143 19596243

McKenzie et al. 2014. Science. 346(6207):318-22. PMID: 25324381.

Koenning et al. 2012. J Neurosci. 32(36):12528-42. PMID: 22956843.

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