Cat. #156375
Anti-BARA/LIN-9 [mAb#1]
Cat. #: 156375
Unit size: 100 ug
Availability: 10-12 weeks
Target: b-Chain Associated Regulator of Apoptosis
Class: Monoclonal
Application: FACS ; IP ; WB
Reactivity: Rat ; Human ; Mouse
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Institute: University of Illinois Chicago
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-BARA/LIN-9 [mAb#1]
- Alternate name: BARA, BARPsv, Lin-9, TGS, TGS1, TGS2 or lin-9 DREAM MuvB core complex component
- Research fields: Cell biology;Genetics
- Class: Monoclonal
- Conjugation: Unconjugated
- Reactivity: Rat ; Human ; Mouse
- Host: Mouse
- Application: FACS ; IP ; WB
- Description: LIN-9 regulates cell transformation and proliferation in mammalian cells by inhibiting DNA synthesis. LIN-9 is inhibited by the regulatory subunit of CDK4, cyclin D. Deletion of the first 84 amino acids of Mip/LIN-9 (Mip/LIN-9ÄËĂÂĂÂ84) corrects the CDK4 null phenotype. Therefore, Mip/LIN-9, like the pocket proteins pRB, p107 and p130, is negatively regulated by CDK4. Moreover, the correction of the CDK4 null phenotype is accompanied by a restoration of the expression of genes such as E2F1, E2F3, and cyclin E suggesting that Mip/LIN-9 participates in the regulation of E2F target genes required for the G1/S transition.
- Immunogen: full-length GST-BARA/LIN9-L fusion protein
- Recommended controls: IgG1
Target Details
- Target: b-Chain Associated Regulator of Apoptosis
- Target background: LIN-9 regulates cell transformation and proliferation in mammalian cells by inhibiting DNA synthesis. LIN-9 is inhibited by the regulatory subunit of CDK4, cyclin D. Deletion of the first 84 amino acids of Mip/LIN-9 (Mip/LIN-9ÄËĂÂĂÂ84) corrects the CDK4 null phenotype. Therefore, Mip/LIN-9, like the pocket proteins pRB, p107 and p130, is negatively regulated by CDK4. Moreover, the correction of the CDK4 null phenotype is accompanied by a restoration of the expression of genes such as E2F1, E2F3, and cyclin E suggesting that Mip/LIN-9 participates in the regulation of E2F target genes required for the G1/S transition.
Applications
- Application: FACS ; IP ; WB
Handling
- Format: Liquid
- Unit size: 100 ug
- Shipping conditions: Shipping at 4° C
References
- Sandoval et al. 2006. Exp Cell Res. 312(13):2465-75. PMID: 16730350.
