Cat. #153503
Anti-HuD/HuC/HuB [16A11]
Cat. #: 153503
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 10-12 weeks
Target: HuD
Class: Monoclonal
Application: ELISA ; IHC ; IF ; WB
Reactivity: Human
Host: Mouse
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Institute: Clonegene LLC
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-HuD/HuC/HuB [16A11]
- Alternate name: ELAV-like protein 4
- Research fields: Developmental biology;Genetics;Neurobiology
- Clone: 16A11
- Tool sub type: Primary antibody
- Class: Monoclonal
- Purpose: Marker
- Conjugation: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: ELISA ; IHC ; IF ; WB
- Description: Monoclonal antibody which recognises HuD, HuC and HuB neuronal proteins.Background and Research ApplicationHuD otherwise known as ELAV-like protein 4 is a protein that in humans is encoded by the ELAVL4 gene. The HuD/ELAVL4 protein is an RNA-binding protein. Diseases associated with ELAVL4 include Lambert-Eaton Myasthenic Syndrome and Sensory Peripheral Neuropathy. HuD is expressed only in neurons and it binds to AU-rich element-containing mRNAs. As a result of this interaction the half-life of the transcript is increased. HuD is important in neurons during brain development and plasticity.The 16A11 anti-HuD monoclonal is now a classic reagent for the identification of neurons. Antibody 16A11 recognizes the ELAV family members HuC, HuD and Hel-N1 neuronal proteins. It does not recognize HuR, another ELAV family member that is present in all proliferating cells. The antibody has been shown to specifically label neuronal cells in zebrafish, chick, canaries, and humans, and is likely to label neuronal cells in most vertebrate species.
- Immunogen: Peptide
- Immunogen uniprot id: P26378
- Isotype: IgG2b
Target Details
- Target: HuD
- Tissue cell line specificity: Mouse
- Target background: Monoclonal antibody which recognises HuD, HuC and HuB neuronal proteins. Background and Research Application HuD otherwise known as ELAV-like protein 4 is a protein that in humans is encoded by the ELAVL4 gene. The HuD/ELAVL4 protein is an RNA-binding protein. Diseases associated with ELAVL4 include Lambert-Eaton Myasthenic Syndrome and Sensory Peripheral Neuropathy. HuD is expressed only in neurons and it binds to AU-rich element-containing mRNAs. As a result of this interaction the half-li...
Applications
- Application: ELISA ; IHC ; IF ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage conditions: Store at -20° C frozen. Avoid repeated freeze / thaw cycles
- Shipping conditions: Shipping at 4° C
