Anti-V(beta)3 T cell receptor (TcR) [JOVI.3]

Monoclonal antibody used in the study of T cell diseases, and as a CAR therapy in T cell lymphoma/leukaemia. This antibody recognises human T cell receptor with the V beta 3 region

Contributors

Inventor Institute
Mike Owen Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Cat. #: 152627
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cell biology;Immunology;Immuno-oncology;Immunophenotyping
Application: FACS ; IHC ; IP ; Fn
Target: V(beta)3 T cell receptor (TcR)
Reactivity: Human
Clone: JOVI.3
Host: Mouse
Class: Monoclonal
Product description: Monoclonal antibody used in the study of T cell diseases, and as a CAR therapy in T cell lymphoma/leukaemia. Background and Research Application The T cell receptor is heterodimer of alpha/beta or gamma/delta chains, expressed on all mature T cells. TCR's recognise antigen peptides bound to MHC molecules, providing the basis of antigen specific response by T cells. JOVI.3 can be used for studies of T cell mediated diseases, including autoimmunity and allergy. The antibody recognises any human T cell receptor that has the V beta 3 region, staining 50-75% of peripheral blood T cells and T cell lines.
Conjugation: Unconjugated
Isotype: IgG2a
Immunogen: Thymus, spleen and mesenteric lymph nodes isolated from a mouse transgenic for human Vb3 TcR.
Immunogen Uniprot ID: P09693
Myeloma used: P3/NS1/1-Ag4.1
Target background: Monoclonal antibody used in the study of T cell diseases, and as a CAR therapy in T cell lymphoma/leukaemia. Background and Research Application The T cell receptor is heterodimer of alpha/beta or gamma/delta chains, expressed on all mature T cells. TCR's recognise antigen peptides bound to MHC molecules, providing the basis of antigen specific response by T cells. JOVI.3 can be used for studies of T cell mediated diseases, including autoimmunity and allergy. The antibody recognises any human T cell receptor that has the v?3 region, staining 50-75% % of peripheral blood T cells and T cell lines.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: Store at -20° C frozen. Avoid repeated freeze / thaw cycles
Shipping conditions: Dry ice
References:

Viguier et al. 2015. J Invest Dermatol. 135(2):418-24. PMID: 25207820.

Peripheral and local human papillomavirus 16-specific CD8+ T-cell expansions characterize erosive oral lichen planus.

San Jos et al. 1999. J Biol Chem. 274(47):33740-6. PMID: 10559266.

Receptor engagement transiently diverts the T cell receptor heterodimer from a constitutive degradation pathway.

Sahuquillo et al. 1998. J Exp Med. 187(8):1179-92. PMID: 9547330.

T cell receptor (TCR) engagement in apoptosis-defective, but interleukin 2 (IL-2)-producing, T cells results in impaired ZAP70/CD3-zeta association.

Viney et al. 1992. Hybridoma. 11(6):701-13. PMID: 1284120.

Generation of monoclonal antibodies against a human T cell receptor beta chain expressed in transgenic mice.

Images

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IHC staining of T cells

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