TAL-1 is a member of the helix-loop-helix family of transcription factors. Overexpression of the TAL-1 gene is the most common molecular abnormality found in human T cell leukaemia.
| Inventor | Institute |
|---|---|
| Karen Pulford | University of Oxford |
| Cat. #: | 151660 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell biology;Developmental biology;Genetics;Stem cell biology |
| Application: | IHC ; IP |
| Target: | TAL1 |
| Reactivity: | Human |
| Clone: | 2TL75 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | TAL-1 is a member of the helix-loop-helix family of transcription factors. Overexpression of the TAL-1 gene is the most common molecular abnormality found in human T cell leukaemia. |
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| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Immunogen: | Recombinant protein |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Target background: | TAL-1 is a member of the helix-loop-helix family of transcription factors. Overexpression of the TAL-1 gene is the most common molecular abnormality found in human T cell leukaemia. |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Delabesse et al. 1998. Br J Haematol. 102(2):449-57. PMID: 9695959. TAL1 expression does not occur in the majority of T-ALL blasts. Bernard et al. 1995. Blood. 85(11):3356-7. PMID: 7756670. Nuclear localization of the SCL/TAL1 basic helix-loop-helix protein is not dependent on the presence of the basic domain. Pulford et al. 1995. Blood. 85(3):675-84. PMID: 7833471. Expression of TAL-1 proteins in human tissues. |
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