Cat. #151501
Anti-LewisA [PR 5C5] mAb
Cat. #: 151501
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-4 weeks
Target: Lewis A antigen
Class: Monoclonal
Application: ELISA ; IHC
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Walter Bodmer
Institute: University of Oxford
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-LewisA [PR 5C5] mAb
- Research fields: Immunology;Tissue-specific biology
- Clone: PR 5C5
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Strain: Balb/c
- Reactivity: Human
- Host: Mouse
- Application: ELISA ; IHC
- Description: PR 5C5 is useful for histological diagnosis of colon disorders and has wide reactivity with bowel, small intestine, stomach and colo-rectal tumours.
- Immunogen: Mucosal scrapings and membrane preparations from normal colorectal epithelium and possibly booster inoculations with the colon carcinoma cell line HT29.
- Isotype: IgG1
- Myeloma used: P3/NS1/1-Ag4.1
Target Details
- Target: Lewis A antigen
- Target background: Lewis a antigen is expressed on colonic mucus, epithelial cells and cell membranes. Blood group related antigens represent a group of carbohydrate determinants carried on both glycolipids and glycoproteins. They are usually mucin-type, and are detected on erythrocytes, certain epithelial cells, and in secretions of certain individuals. Sixteen genetically and biosynthetically distinct but inter-related specificities belong to this group of antigens, including A, B, H, Lewis A, Lewis B, Lewis X, Lewis Y, and precursor type 1 chain antigens.
Applications
- Application: ELISA ; IHC
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
References
- Richman et al. 1987. Int J Cancer. 39(3):317-28. PMID: 2434440.
- Monoclonal antibodies to human colorectal epithelium: markers for differentiation and tumour characterization.
