Monoclonal antibody capable of HLA typing, reacting with subregions of class II antigens.
| Inventor | Institute |
|---|---|
| Jacqueline Cordell | University of Oxford |
| Cat. #: | 151383 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Immunology |
| Application: | FACS ; IHC ; WB |
| Target: | Human Leukocyte Antigen DR (MHC class II) |
| Reactivity: | Human |
| Clone: | CR3/43 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | Monoclonal antibody capable of HLA typing, reacting with subregions of class II antigens. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | Tonsil cells |
| Immunogen Uniprot ID: | P01903 |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Target background: | Human Leukocyte Antigens (HLA) are highly polymorphic proteins that are involved in the presentation of antigens to the T-cell receptor. There are two classes of HLA antigens, class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. The human MHC class II molecules bind intracellularly processed peptides and present them to T helper cells. … |
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| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | Store at -20° C frozen. Avoid repeated freeze / thaw cycles |
| Shipping conditions: | Dry ice |
| References: |
Baiardi et al. 2019. Ann Clin Transl Neurol. 6(2):263-273. PMID: 30847359. Kalsow et al. 2017. Ocul Immunol Inflamm. 25(6):878-883. PMID: 27715362. Kagami et al. 2017. J Clin Exp Hematop. 57(1):9-14. PMID: 28420813. van Duijn et al. 2017. J Alzheimers Dis. 60(4):1533-1545. PMID: 29081415. Breshears et al. 2012. J Biol Chem. 287(39):32578-87. PMID: 22833676. A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial resp… |
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