Cig2 is a fission yeast (S. pombe) B-type S-phase cyclin and is expressed in a sharp spike peaking at G1/S period. Cig2 binds to Cdc2 (Cdk1), and the resulting Cdc2-Cig2 complex controls the G1/S transition of the cell cycle.
| Institute |
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| Cancer Research UK, London Research Institute: Clare Hall Laboratories |
| Cat. #: | 151210 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell biology;Cell signaling and signal transduction |
| Application: | ELISA ; IHC ; IF ; IP ; WB |
| Target: | Cig2 |
| Reactivity: | Schizosaccharomyces pombe |
| Clone: | CIG2 3A11/5 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | Cyc17 |
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| Product description: | Cig2 is a fission yeast (S. pombe) B-type S-phase cyclin and is expressed in a sharp spike peaking at G1/S period. Cig2 binds to Cdc2 (Cdk1), and the resulting Cdc2-Cig2 complex controls the G1/S transition of the cell cycle. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | S. pombe Cig2 purified protein (bacterial expression) |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | Cig2 is a fission yeast (S. pombe) B-type S-phase cyclin and is expressed in a sharp spike peaking at G1/S period. Cig2 binds to Cdc2 (Cdk1), and the resulting Cdc2-Cig2 complex controls the G1/S transition of the cell cycle. |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Chu et al. 2009. Mol Cell Biol. 29(18):4959-70. PMID: 19596787. A Cds1-mediated checkpoint protects the MBF activator Rep2 from ubiquitination by anaphase-promoting complex/cyclosome-Ste9 at S-phase arrest in fission yeast. Chu et al. 2007. Mol Biol Cell. 18(5):1756-67. PMID: 17332498. Modulation of cell cycle-specific gene expressions at the onset of S phase arrest contributes to the robust DNA replication checkpoint response in fission yeast. Yamano et al. 2000. Mol Cell. 6(6):1377-87. PMID: 11163211. The spike of S phase cyclin Cig2 expression at the G1-S border in fission yeast requires both APC and SCF ubiquitin ligases. |
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