Anti-AP2 (a&b) [A6/2/2]

AP-2 is a family of developmentally regulated transcription factors which also play a role in breast cancer and melanoma. AP-2?Ÿ may be important in cardiac and kidney development. The AP-2 transcription factors form the OB2 complex that has been shown to up-regulate c-erb-B2 transcription.

Contributors

Inventor Institute
Helen Hurst Queen Mary University of London
Cat. #: 151069
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cancer;Tissue-specific biology;Genetics
Application: ELISA ; FACS ; IHC ; IF ; RIA ; WB
Target: Activating Protein 2 (AP-2) alpha and beta forms.
Reactivity: Human
Clone: A6/2/2
Host: Mouse
Class: Monoclonal
Product description: AP-2 is a family of developmentally regulated transcription factors which also play a role in breast cancer and melanoma. AP-2?Ÿ may be important in cardiac and kidney development. The AP-2 transcription factors form the OB2 complex that has been shown to up-regulate c-erb-B2 transcription.
Conjugation: Unconjugated
Isotype: IgG1
Immunogen: Peptide to C-Terminal of AP-2 Alpha coupled to KLH. PNSHTDNNAKSSDKEEKHRK
Myeloma used: NS0
Target background: AP-2 is a family of developmentally regulated transcription factors which also play a role in breast cancer and melanoma. AP-2? may be important in cardiac and kidney development. The AP-2 transcription factors form the OB2 complex that has been shown to up-regulate c-erb-B2 transcription.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Yang et al. 2005. J Am Soc Nephrol. 16(10):2890-6. PMID: 16107581.

Redistribution of myosin VI from top to base of proximal tubule microvilli during acute hypertension.

Gee et al. 1999. J Pathol. 189(4):514-20. PMID: 10629551.

Immunohistochemical analysis reveals a tumour suppressor-like role for the transcription factor AP-2 in invasive breast cancer.

Batsch et al. 1998. Mol Cell Biol. 18(7):3647-58. PMID: 9632747.

RB and c-Myc activate expression of the E-cadherin gene in epithelial cells through interaction with transcription factor AP-2.

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