The c-Myc and N-Myc oncogenes are members of the Myc family of transcription factors that regulate cell proliferation and apoptosis. c-Myc is expressed in proliferating tissues and increased c-Myc expression is found in many cancers. N-Myc is amplified in a proportion of neuroblastoma patients.
| Inventor | Institute |
|---|---|
| Gerard Evan | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151068 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Cancer types: | Gynaecologic cancer;Digestive / Gastrointestinal cancer;Breast cancer;Lung cancer |
| Research Fields: | Cancer;Cell biology;Genetics;Stem cell biology |
| Application: | ChIP ; FACS ; IHC ; IP ; WB |
| Target: | cMyc |
| Reactivity: | Human |
| Clone: | Array |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | The c-Myc and N-Myc oncogenes are members of the Myc family of transcription factors that regulate cell proliferation and apoptosis. c-Myc is expressed in proliferating tissues and increased c-Myc expression is found in many cancers. N-Myc is amplified in a proportion of neuroblastoma patients. |
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| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Immunogen: | Residues 408-420. AEEQKLISEEDL. |
| Immunogen Uniprot ID: | P01106 |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | The c-Myc and N-Myc oncogenes are members of the Myc family of transcription factors that regulate cell proliferation and apoptosis. c-Myc is expressed in proliferating tissues and increased c-Myc expression is found in many cancers. N-Myc is amplified in a proportion of neuroblastoma patients. |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Mittal et al. 2013. PLoS One. 8(8):e70352. PMID: 23936412. Role of CTLA4 in the proliferation and survival of chronic lymphocytic leukemia. Mirzaei et al. 2013. Proc Natl Acad Sci U S A. 110(9):3645-50. PMID: 23388641. Systematic measurement of transcription factor-DNA interactions by targeted mass spectrometry identifies candidate gene regulatory proteins. Keyhanfar et al. 2007. Biochem J. 401(1):269-77. PMID: 16981855. Precise mapping of an IGF-I-binding site on the IGF-1R. Halm… |
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